دورية أكاديمية
Sustained high proportion of zidovudine-resistant HIV variants despite prolonged substitution of zidovudine by other nucleoside reverse transcriptase inhibitors.
| العنوان: | Sustained high proportion of zidovudine-resistant HIV variants despite prolonged substitution of zidovudine by other nucleoside reverse transcriptase inhibitors. |
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| المؤلفون: | Bélec L; Laboratoire de virologie, Hôpital Européen Georges Pompidou, Paris, France. laurent.belec@egp.ap-hop-paris.fr, Legoff J, Si-Mohamed A, Andréoletti L, Mbopi-Kéou FX, Kolberg J, Matta M, Detmer J, Piketty C, Kazatchkine MD |
| المصدر: | Journal of medical virology [J Med Virol] 2002 Sep; Vol. 68 (1), pp. 1-6. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Print ISSN: 0146-6615 (Print) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York Ny : Wiley-Liss Original Publication: New York, Liss. |
| مواضيع طبية MeSH: | Genetic Variation*, Anti-HIV Agents/*pharmacology , HIV Seropositivity/*virology , HIV-1/*drug effects , Reverse Transcriptase Inhibitors/*pharmacology , Zidovudine/*pharmacology, Adaptation, Physiological/genetics ; Adult ; Anti-HIV Agents/therapeutic use ; Dideoxynucleosides/pharmacology ; Dideoxynucleosides/therapeutic use ; Drug Resistance, Viral ; Female ; Genotype ; HIV Seropositivity/drug therapy ; HIV-1/genetics ; Humans ; Male ; Middle Aged ; Prevalence ; Prospective Studies ; Reverse Transcriptase Inhibitors/therapeutic use ; Time Factors ; Zidovudine/therapeutic use |
| مستخلص: | The consequences of zidovudine (ZDV) replacement by other nucleoside reverse transcriptase inhibitors on the expression of resistance mutations at codons 215 and 41 of the reverse transcriptase (RT) gene was investigated prospectively in 66 patients harboring mutant genotypes who were changed to an effective two- or three-drug combination antiretroviral regimen. Quantitation of mutant (MUT) viral populations at codon 215 by means of RT-PCR with differential hybridization of amplicons specific for MUT and wild (WT) variants revealed no difference in the proportion of 215 MUT variants prior to (93.5 +/- 2.4%) and 12 to 20 months after (96.9 +/- 1.9%) ZDV replacement, independently of a therapeutic change for stavudine. The fitness of the variants harboring the ZDV-resistant MUT 215 genotype following drug withdrawal was calculated to be 96 to 99% of that of the variants harboring the WT 215 genotype. The apparent stability of ZDV-resistant variants in the study population may have two main complementary explanations: persistent selective pressure secondary to partial cross-resistance due to the new regimens given after the therapeutic alteration and suppression of viral replication after the therapeutic alteration that could have hampered the replacement of less fit variants by fitter variants. These findings indicate that, at least within 15 months following discontinuation of ZDV, an effective antiretroviral therapy is insufficient to allow for ZDV-resistant strains to disappear, and thus to allow for the safe re-introduction of the drug. (Copyright 2002 Wiley-Liss, Inc.) |
| المشرفين على المادة: | 0 (Anti-HIV Agents) 0 (Dideoxynucleosides) 0 (Reverse Transcriptase Inhibitors) 4B9XT59T7S (Zidovudine) |
| تواريخ الأحداث: | Date Created: 20020905 Date Completed: 20021203 Latest Revision: 20131121 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1002/jmv.10162 |
| PMID: | 12210423 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0146-6615 |
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| DOI: | 10.1002/jmv.10162 |