دورية أكاديمية
Frequent loss of p53 codon 72 Pro variant in hepatitis C virus-positive carriers with hepatocellular carcinoma.
| العنوان: | Frequent loss of p53 codon 72 Pro variant in hepatitis C virus-positive carriers with hepatocellular carcinoma. |
|---|---|
| المؤلفون: | Anzola M; Departamento de Z y Dinámica Celular, Facultad de Farmacia, Universidad del País Vasco, Paseo Universidad 7, 01006 Vitoria, Spain., Cuevas N, López-Martínez M, Saiz A, Burgos JJ, de Pancorbo MM |
| المصدر: | Cancer letters [Cancer Lett] 2003 Apr 25; Vol. 193 (2), pp. 199-205. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print Cited Medium: Print ISSN: 0304-3835 (Print) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Science Ireland Original Publication: Amsterdam, Elsevier/North-Holland. |
| مواضيع طبية MeSH: | Genes, p53* , Polymorphism, Genetic*, Carcinoma, Hepatocellular/*genetics , Carcinoma, Hepatocellular/*virology , Hepatitis C/*genetics , Liver Neoplasms/*genetics , Liver Neoplasms/*virology, Adult ; Aged ; Alleles ; Cell Differentiation ; Codon ; Female ; Haplotypes ; Humans ; Loss of Heterozygosity ; Male ; Middle Aged ; Polymorphism, Single-Stranded Conformational ; Prognosis ; Risk |
| مستخلص: | Codon 72 exon 4 polymorphism of the p53 gene has been implicated in cancer risk and it has been suggested that it may have an impact on the clinical outcome of the disease. Our objective was to evaluate the association between p53 polymorphism at codon 72 and hepatocellular carcinoma. The p53 codon 72 genotype was examined in 97 biopsy samples from 67 Basque patients histologically diagnosed with hepatocellular carcinoma. Blood samples collected from 111 Basque residents were examined as a control group. The polymorphism was examined by both single strand conformation polymorphism analysis and allele specific polymerase chain reaction. Fisher's exact test was used to evaluate the data. The results showed that there were no statistically significant differences in the frequency of codon 72 polymorphism genotype between patients with liver cancer and healthy controls. We found a frequent loss of proline allele in hepatitis C virus (HCV)-positive carriers. In conclusion, the lack of a significant relationship between this polymorphism and risk of hepatocellular carcinoma suggests that it does not predispose towards hepatocarcinogenesis in this population. We suggest that the frequent loss of the proline allele in HCV-associated carcinogenesis of the liver plays some role in hepatocarcinogenesis. |
| المشرفين على المادة: | 0 (Codon) |
| تواريخ الأحداث: | Date Created: 20030423 Date Completed: 20030627 Latest Revision: 20190720 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/s0304-3835(03)00046-6 |
| PMID: | 12706878 |
| قاعدة البيانات: | MEDLINE |
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