دورية أكاديمية
Immunogenicity of GM-CSF products in cancer patients following immunostimulatory therapy with GM-CSF.
| العنوان: | Immunogenicity of GM-CSF products in cancer patients following immunostimulatory therapy with GM-CSF. |
|---|---|
| المؤلفون: | Wadhwa M; Division of Immunobiology, National Institute for Biological Standards and Control, Potters Bar, Herts, UK. mwadhwa@nibsc.ac.uk, Mellstedt H, Small E, Thorpe R |
| المصدر: | Developments in biologicals [Dev Biol (Basel)] 2003; Vol. 112, pp. 61-7. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 100940058 Publication Model: Print Cited Medium: Print ISSN: 1424-6074 (Print) Linking ISSN: 14246074 NLM ISO Abbreviation: Dev Biol (Basel) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel ; New York : Karger, c2000- |
| مواضيع طبية MeSH: | Colorectal Neoplasms/*therapy , Granulocyte-Macrophage Colony-Stimulating Factor/*immunology, Autoantibodies/analysis ; Autoantibodies/immunology ; Granulocyte-Macrophage Colony-Stimulating Factor/administration & dosage ; Granulocyte-Macrophage Colony-Stimulating Factor/therapeutic use ; Humans ; Neutralization Tests |
| مستخلص: | There is a high risk of developing neutralising and non-neutralising antibodies when GM-CSF is used as an immunomodulatory agent in non-immunocompromised patients. The presence of neutralising antibodies may seriously hamper the clinical response of the patients. This must be taken into account when designing protocols if the biological activity of the exogenously administered GM-CSF is not to be impaired and the endogenous production of GM-CSF is not to be inactivated. Assessment of production of neutralising antibodies during cytokine therapy is important for predicting the clinical response to progressive therapy. Use of validated assays is imperative for evaluation of antibodies generated following therapy with a particular protein. |
| المشرفين على المادة: | 0 (Autoantibodies) 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor) |
| تواريخ الأحداث: | Date Created: 20030524 Date Completed: 20030801 Latest Revision: 20041117 |
| رمز التحديث: | 20221213 |
| PMID: | 12762505 |
| قاعدة البيانات: | MEDLINE |
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