دورية أكاديمية
The accuracy of 1-day dual-isotope myocardial SPECT in a population with high prevalence of coronary artery disease.
| العنوان: | The accuracy of 1-day dual-isotope myocardial SPECT in a population with high prevalence of coronary artery disease. |
|---|---|
| المؤلفون: | Groutars RG; Department of Cardiology, University Hospital, Leiden, The Netherlands., Verzijlbergen JF, Tiel-van Buul MM, Zwinderman AH, Ascoop CA, van Hemel NM, van der Wall EE |
| المصدر: | The international journal of cardiovascular imaging [Int J Cardiovasc Imaging] 2003 Jun; Vol. 19 (3), pp. 229-38. |
| نوع المنشور: | Comparative Study; Evaluation Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 100969716 Publication Model: Print Cited Medium: Print ISSN: 1569-5794 (Print) Linking ISSN: 15695794 NLM ISO Abbreviation: Int J Cardiovasc Imaging Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [New York] : Springer Original Publication: Boston : Kluwer Academic Publishers, c2001- |
| مواضيع طبية MeSH: | Radiopharmaceuticals* , Tomography, Emission-Computed, Single-Photon*, Cardiomyopathies/*diagnosis , Coronary Artery Disease/*diagnosis, Adenosine ; Adult ; Aged ; Aged, 80 and over ; Cardiomyopathies/epidemiology ; Cardiomyopathies/physiopathology ; Coronary Angiography ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/physiopathology ; Echocardiography ; Exercise Test ; False Positive Reactions ; Female ; Humans ; Male ; Middle Aged ; Organophosphorus Compounds ; Organotechnetium Compounds ; Predictive Value of Tests ; Prevalence ; Risk Factors ; Sensitivity and Specificity ; Statistics as Topic ; Stroke Volume/physiology ; Vasodilator Agents |
| مستخلص: | Background: In order to evaluate the diagnostic efficacy of the 1-day separate acquisition dual-isotope single-photon emission computed tomography (SPECT) protocol, using 201Tl for the rest and 99mTc-tetrofosmin for the stress images, a consecutive series of patients with suspected or known coronary artery disease (CAD) was studied that also underwent coronary angiography. Methods: The results of myocardial SPECT, using a semi-quantitative visual analysis, were acquired in 123 patients and compared with the results of coronary angiography. Sensitivity and specificity were calculated, using thresholds of > or = 50 and > or = 70% stenosis. As an alternative for specificity, the normalcy rate was determined in a separate group of 87 patients with a < 5% pre-test likelihood of CAD. Results: The prevalence of CAD using > or =50 and > or = 70% stenosis was 88 and 78%, respectively. The sensitivity for detection of patients with > or = 50 and > or = 70% stenosis was 94 and 97%, respectively while specificity was 62 and 59%, respectively. The high rate of false positive perfusion defects resulting in a low specificity could be explained by specific clinical issues. However, the routine assessment with additional clinical and electrocardiographic data resulted in a correct interpretation of most of the false positive perfusion defects. The positive predictive value was 92 and 85% and the negative predictive value 46 and 77%, using thresholds of > or = 50 and > or = 70% stenosis, respectively. The normalcy rate was 91%. Conclusion: The one-day separate acquisition rest 201Tl/stress 99mTc-tetrofosmin SPECT protocol is an efficient procedure for myocardial perfusion scintigraphy with high sensitivity for detection of CAD. Specific clinical issues caused a low value for specificity. Therefore, clinical information and knowledge of the electrocardiogram is essential for a correct interpretation of SPECT images. |
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| المشرفين على المادة: | 0 (Organophosphorus Compounds) 0 (Organotechnetium Compounds) 0 (Radiopharmaceuticals) 0 (Vasodilator Agents) 42FOP1YX93 (technetium tc-99m tetrofosmin) K72T3FS567 (Adenosine) |
| تواريخ الأحداث: | Date Created: 20030702 Date Completed: 20031211 Latest Revision: 20191210 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1023/a:1023637804898 |
| PMID: | 12834160 |
| قاعدة البيانات: | MEDLINE |
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