دورية أكاديمية
In vitro trypanocidal activity of dibutyltin dichloride and its fatty acid derivatives.
| العنوان: | In vitro trypanocidal activity of dibutyltin dichloride and its fatty acid derivatives. |
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| المؤلفون: | Shuaibu MN; Protozoology Department, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki-shi 852-8523, Japan., Kanbara H, Yanagi T, Ichinose A, Ameh DA, Bonire JJ, Nok AJ |
| المصدر: | Parasitology research [Parasitol Res] 2003 Sep; Vol. 91 (1), pp. 5-11. Date of Electronic Publication: 2003 Jul 08. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 8703571 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0932-0113 (Print) Linking ISSN: 09320113 NLM ISO Abbreviation: Parasitol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : Springer International, c1987- |
| مواضيع طبية MeSH: | Fatty Acids/*chemistry , Organotin Compounds/*pharmacology , Trypanocidal Agents/*pharmacology , Trypanosoma/*drug effects, Animals ; Mice ; Microscopy, Electron ; Microscopy, Electron, Scanning ; Organotin Compounds/chemistry ; Parasitic Sensitivity Tests ; Trypanosoma/growth & development ; Trypanosoma/ultrastructure ; Trypanosoma brucei brucei/drug effects ; Trypanosoma brucei brucei/growth & development ; Trypanosoma brucei brucei/ultrastructure ; Trypanosoma brucei gambiense/drug effects ; Trypanosoma brucei gambiense/growth & development ; Trypanosoma brucei gambiense/ultrastructure ; Trypanosoma brucei rhodesiense/drug effects ; Trypanosoma brucei rhodesiense/growth & development ; Trypanosoma brucei rhodesiense/ultrastructure |
| مستخلص: | Searching for new compounds against pathogenic trypanosomes has been substantially accelerated by the development of in vitro screening assays. In an attempt to explore the chemotherapeutic potential of organotin compounds and to broaden the search for newer trypanocides, fatty acid derivatives of dibutyltin dichloride were synthesized and their in vitro trypanocidal profiles studied on Trypanosoma brucei brucei, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense. A 24-h time course experiment was conducted with various concentrations of the compounds using a 24-well microtiter plate technique. The compounds tested were trypanocidal in a dose-dependent fashion: inhibiting survival and growth, resulting in irreversible morphological deformation and the eventual death of the parasites. The minimum inhibitory concentrations of the tested diorganotins are at low micromolar ranges: from 0.15-0.75 microM for T. b. brucei, T. b. gambiense and T. b. rhodesiense. These observations suggest that organotin has chemotherapeutic potential. |
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| المشرفين على المادة: | 0 (Fatty Acids) 0 (Organotin Compounds) 0 (Trypanocidal Agents) J4AQN88R8P (dibutyldichlorotin) L4061GMT90 (dibutyltin dilaurate) |
| تواريخ الأحداث: | Date Created: 20030710 Date Completed: 20040120 Latest Revision: 20181113 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s00436-003-0861-2 |
| PMID: | 12851812 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 0932-0113 |
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| DOI: | 10.1007/s00436-003-0861-2 |