دورية أكاديمية
Occupational asthma due to IgE mediated allergy to the flower Molucella laevis (Bells of Ireland).
| العنوان: | Occupational asthma due to IgE mediated allergy to the flower Molucella laevis (Bells of Ireland). |
|---|---|
| المؤلفون: | Miesen WM; Department of Allergology, Clinic for Internal Medicine, Groningen University Hospital, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, Netherlands. w.m.a.j.miesen@int.azg.nl, van der Heide S, Kerstjens HA, Dubois AE, de Monchy JG |
| المصدر: | Occupational and environmental medicine [Occup Environ Med] 2003 Sep; Vol. 60 (9), pp. 701-3. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 9422759 Publication Model: Print Cited Medium: Print ISSN: 1351-0711 (Print) Linking ISSN: 13510711 NLM ISO Abbreviation: Occup Environ Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BMJ Pub. Group, c1994- |
| مواضيع طبية MeSH: | Occupational Exposure*, Allergens/*adverse effects , Asthma/*etiology , Immunoglobulin E/*adverse effects , Occupational Diseases/*etiology , Pollen/*adverse effects, Air Pollutants, Occupational/adverse effects ; Air Pollutants, Occupational/analysis ; Albuterol/therapeutic use ; Asthma/drug therapy ; Bronchodilator Agents/therapeutic use ; Humans ; Male ; Middle Aged ; Treatment Outcome |
| مستخلص: | Background: About 25% of greenhouse flower and/or ornamental plant growers sensitised to workplace flowers or moulds have occupational asthma, a disease that is suffered by 8% of the growers who cultivate these crops. Aim: To document a case of occupational asthma due to IgE mediated allergy to the flower Molucella laevis. Methods: and Results: There was a history of work related seasonal asthmatic and rhinoconjunctivitis symptoms in a Molucella laevis grower. Bronchial obstruction following exposure to Molucella laevis was documented by a fall in FEV(1) from 89% to 73% of predicted during seasonal exposure to Molucella laevis. Daily PEF measurements showed a fall from 500 to 250 l/min during this period following withdrawal of inhaled steroids. Bronchial reactivity to inhaled methacholine was increased (PC(20) 1.45 mg/ml). Confirmation of sensitisation to Molucella laevis flower pollen extract was done using an SPT and by demonstration of Molucella laevis specific serum IgE (18 IU/ml; class 4). Specific inhalation challenge with Molucella laevis extract provoked an early and late asthmatic reaction (EAR and LAR) with a fall in FEV(1) compared with control day of 40% and 53% respectively, with associated 5.1-fold increase in absolute sputum eosinophil cell counts and 2.9-fold increase in neutrophil cell counts. |
| المشرفين على المادة: | 0 (Air Pollutants, Occupational) 0 (Allergens) 0 (Bronchodilator Agents) 37341-29-0 (Immunoglobulin E) QF8SVZ843E (Albuterol) |
| تواريخ الأحداث: | Date Created: 20030826 Date Completed: 20031016 Latest Revision: 20190503 |
| رمز التحديث: | 20240627 |
| مُعرف محوري في PubMed: | PMC1740630 |
| DOI: | 10.1136/oem.60.9.701 |
| PMID: | 12937197 |
| قاعدة البيانات: | MEDLINE |
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