دورية أكاديمية
[A change in antigen presentation ability of spleen macrophage from Balb/c mouse during late pregnancy].
| العنوان: | [A change in antigen presentation ability of spleen macrophage from Balb/c mouse during late pregnancy]. |
|---|---|
| المؤلفون: | Tan Z; Department of Reproduction & Immunological, West China Second Hospital, Sichuan University, Chendu 610041, China., Li S, Cao Z, Zhao Z, Ma Q, Huang Z, Li L |
| المصدر: | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition [Sichuan Da Xue Xue Bao Yi Xue Ban] 2003 Oct; Vol. 34 (4), pp. 674-7. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Sichuan da xue xue bao (yi xue ban) bian ji bu Country of Publication: China NLM ID: 101162609 Publication Model: Print Cited Medium: Print ISSN: 1672-173X (Print) Linking ISSN: 1672173X NLM ISO Abbreviation: Sichuan Da Xue Xue Bao Yi Xue Ban Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Chengdu Shi : Sichuan da xue xue bao (yi xue ban) bian ji bu, 2003- |
| مواضيع طبية MeSH: | Immune Tolerance*, Antigen-Presenting Cells/*immunology , Macrophages/*immunology , Spleen/*cytology, Animals ; Female ; Globulins/immunology ; Lymphocyte Activation ; Mice ; Mice, Inbred BALB C ; Pregnancy ; Random Allocation ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology |
| مستخلص: | Objective: To study the antigen presentation ability of spleen macrophage from Balb/c mouse during late gestation. Methods: The spleen of Balb/c mouse during late gestation was collected aseptically and macrophage was separated; the mice in estrus were used as control. The ability of macrophage to prime original T cells to human gamma globulin antigen (HGG-Ag) or placenta antigen (Pla-Ag) was evaluated by a delayed-type hyper sensitivity (DTH) response induced by the same antigen, and the ability of macrophage to induce the proliferation of primed normal T cells to HGG-Ag or Pla-Ag was assessed by an antigen special lymphocyte transformation in vitro. Results: After being sensitized previously by spleen macrophage from Balb/c mice during late gestation that has been pulsed by HGG-Ag or Pla-Ag, the DTH intensity of mice response to the same antigen was significantly weaker than that being sensitized by macrophage from mice in estrus (P < 0.05). When spleen macrophage from Balb/c mice during late gestation was used as antigen presentation cell (APC), the proliferability of primed T cell induced by HGG-Ag or Pla-ag was significantly lower than that when macrophage from estrous Balb/c mouse was used in vitro (P < 0.05). Conclusion: The antigen presentation ability of spleen macrophage from Balb/c mouse is inhibited during late pregnancy. This may be the important mechanism by which maternal immune system tolerates embryo antigen and may be responsible for the down-regulation of maternal cell mediated immunity during pregnancy. |
| المشرفين على المادة: | 0 (Globulins) |
| تواريخ الأحداث: | Date Created: 20031119 Date Completed: 20040803 Latest Revision: 20061115 |
| رمز التحديث: | 20231215 |
| PMID: | 14619578 |
| قاعدة البيانات: | MEDLINE |
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