دورية أكاديمية
Ratio between positive lymph nodes and total dissected axillaries lymph nodes as an independent prognostic factor for disease-free survival in patients with breast cancer.
| العنوان: | Ratio between positive lymph nodes and total dissected axillaries lymph nodes as an independent prognostic factor for disease-free survival in patients with breast cancer. |
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| المؤلفون: | Megale Costa LJ; Department of Internal Medicine, University of São Paulo, São Paulo, Brazil., Soares HP, Gaspar HA, Trujillo LG, Santi PX, Pereira RS, de Santana TL, Pinto FN, del Giglio A |
| المصدر: | American journal of clinical oncology [Am J Clin Oncol] 2004 Jun; Vol. 27 (3), pp. 304-6. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8207754 Publication Model: Print Cited Medium: Internet ISSN: 1537-453X (Electronic) Linking ISSN: 02773732 NLM ISO Abbreviation: Am J Clin Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: New York, N.Y. : Masson Pub. USA, c1982- |
| مواضيع طبية MeSH: | Lymph Node Excision* , Lymphatic Metastasis*, Breast Neoplasms/*mortality , Breast Neoplasms/*pathology, Adult ; Axilla ; Breast Neoplasms/therapy ; Chemotherapy, Adjuvant ; Disease-Free Survival ; Female ; Humans ; Middle Aged ; Prognosis ; Retrospective Studies |
| مستخلص: | The number of positive axillary lymph nodes involved by tumor is one of the main prognostic factors for women with locoregional breast cancer (BC) for whom adjuvant chemotherapy is being considered. The prognostic importance of the ratio (P/D) between positive lymph nodes (P) and total dissected lymph nodes (D), previously demonstrated in the high-dose chemotherapy (HDC) setting has not yet been tested, however, in the conventional adjuvant chemotherapy setting. The data of 168 patients who were from 2 institutions and who were treated with adjuvant chemotherapy for BC were retrospectively analyzed, and univariate and multivariate analysis were performed, including the other traditional prognostic factors and P/D ratio as possible predictors of disease free survival (DFS). Disease-free survival for quartile 4 of P/D ratio (ratio >0.30) was statistically different from that for the other quartiles (log-rank test p < 0.001). Mean DFS for this series was not reached as well as for quartiles 1, 2, and 3, while mean DFS for quartile 4 was 44.5 months. In univariate analysis, number of positive lymph nodes (r2 = 0.055; p = 0.023), P/D ratio (r2 = 0.213; p < 0.001), and stage (r2 = 0.105; p = 0.002) were predictive of relapse, while in multivariate analysis, only P/D ratio remained an independent predictor of relapse (r2 = 0.213; p < 0.001). It is concluded that P/D ratio could become a simple, inexpensive, and easily available prognostic factor for patients undergoing conventional chemotherapy for BC. |
| تواريخ الأحداث: | Date Created: 20040601 Date Completed: 20040830 Latest Revision: 20190906 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1097/01.coc.0000071941.70772.dc |
| PMID: | 15170153 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-453X |
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| DOI: | 10.1097/01.coc.0000071941.70772.dc |