دورية أكاديمية
Drug delivery into the eye with the use of ultrasound.
| العنوان: | Drug delivery into the eye with the use of ultrasound. |
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| المؤلفون: | Zderic V; Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, 1013 NE 40th St, Seattle, WA 98105 USA. vesna@u.washington.edu, Clark JI, Vaezy S |
| المصدر: | Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine [J Ultrasound Med] 2004 Oct; Vol. 23 (10), pp. 1349-59. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley and Sons Country of Publication: England NLM ID: 8211547 Publication Model: Print Cited Medium: Print ISSN: 0278-4297 (Print) Linking ISSN: 02784297 NLM ISO Abbreviation: J Ultrasound Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : Oxford, UK : John Wiley and Sons Original Publication: [Philadelphia, Pa.] : W.B. Saunders, c1982- |
| مواضيع طبية MeSH: | Cornea*/physiology , Drug Delivery Systems* , Phonophoresis* , Ultrasonics*, Fluorescein/*administration & dosage, Animals ; Body Temperature ; Rabbits |
| مستخلص: | Objective: To evaluate ultrasound enhancement of drug delivery through the cornea and the histologic appearance of the cornea up to 24 hours after treatment. Methods: Corneas were exposed to ultrasound at a frequency of 880 kHz and intensities of 0.19 to 0.56 W/cm2 (continuous mode) with an exposure duration of 5 minutes. The aqueous humor concentration of a topically applied hydrophilic dye, sodium fluorescein, was determined quantitatively in ultrasound- and sham-treated rabbit eyes in vivo. Gross and light microscopic examinations were used to observe structural changes in the cornea 0 to 24 hours after ultrasound exposure. Cavitation activity was measured with a passive cavitation detector. Results: Most cells with an appearance different from that of the normal cells were present in the surface layer of the corneal epithelium. No structural changes were observed in the stroma. The increase in dye concentration in the aqueous humor (relative to sham treatment), after the simultaneous application of ultrasound and the dye solution, was 2.4 times at 0.19 W/cm2, 3.8 times at 0.34 W/cm2, and 10.6 times at 0.56 W/cm2 (P <.05). Dye delivery was found to increase with increasing ultrasound intensity, which corresponded to an increase in cavitation activity. Corneal pits, observed in the ultrasound-treated epithelium, completely disappeared within 90 minutes. Conclusions: Application of 880-kHz ultrasound provided up to 10-fold enhancement in the delivery of a hydrophilic compound through the cornea while producing minor changes in the corneal epithelium. |
| معلومات مُعتمدة: | R01 EY004542 United States EY NEI NIH HHS; E404542 United States PHS HHS |
| المشرفين على المادة: | TPY09G7XIR (Fluorescein) |
| تواريخ الأحداث: | Date Created: 20040928 Date Completed: 20050111 Latest Revision: 20190725 |
| رمز التحديث: | 20231215 |
| DOI: | 10.7863/jum.2004.23.10.1349 |
| PMID: | 15448325 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0278-4297 |
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| DOI: | 10.7863/jum.2004.23.10.1349 |