التفاصيل البيبلوغرافية
| العنوان: |
A Bayesian statistical analysis of human T-cell lymphotropic virus evolutionary rates. |
| المؤلفون: |
Lemey P; Rega Institute for Medical Research, Minderbroedersstraat 10, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium. philippe.lemey@uz.kuleuven.ac.be, Pybus OG, Van Dooren S, Vandamme AM |
| المصدر: |
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2005 Apr; Vol. 5 (3), pp. 291-8. Date of Electronic Publication: 2004 Nov 30. |
| نوع المنشور: |
Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 101084138 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1567-1348 (Print) Linking ISSN: 15671348 NLM ISO Abbreviation: Infect Genet Evol Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Amsterdam ; New York : Elsevier Science, c2001- |
| مواضيع طبية MeSH: |
Bayes Theorem* , Biological Evolution*, Primate T-lymphotropic virus 2/*physiology, Human T-lymphotropic virus 1/physiology ; Human T-lymphotropic virus 2/physiology ; Humans ; Pedigree ; Phylogeny ; Primate T-lymphotropic virus 2/genetics |
| مستخلص: |
HTLV is a genetically-stable retrovirus that is considered to have evolved partly in concert with human migrations. Its rate of evolution is low and therefore, difficult to estimate reliably. In the first part of this study, we provide an improved estimate of HTLV evolutionary rate using anthropological calibration of phylogenetic nodes. We investigate two different anthropological calibrations using a Bayesian method that implements a relaxed molecular clock model and can combine data from multiple genes. The analysis shows that the two calibrations are compatible. In the second part, we develop a Bayesian statistical model to combine and compare the anthropology-based estimates of evolutionary rate with a rate recently calculated using pedigree data from vertically HTLV-infected families. We compare the statistical power of the two estimates and show that the current pedigree estimate, although resulting in considerably higher evolutionary rates, is too statistically weak to warrant a re-examination of the commonly used anthropology-based estimates. Statistical uncertainty burdens HTLV rate estimates based on both anthropological calibrations and on pedigree data; the former method rests on an untested assumption, whilst that latter is affected by small sample sizes. |
| تواريخ الأحداث: |
Date Created: 20050302 Date Completed: 20050510 Latest Revision: 20101118 |
| رمز التحديث: |
20231215 |
| DOI: |
10.1016/j.meegid.2004.04.005 |
| PMID: |
15737921 |
| قاعدة البيانات: |
MEDLINE |
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