دورية أكاديمية
Capsazepine, a vanilloid receptor antagonist, inhibits allergen-induced tracheal contraction.
| العنوان: | Capsazepine, a vanilloid receptor antagonist, inhibits allergen-induced tracheal contraction. |
|---|---|
| المؤلفون: | van den Worm E; Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO BOX 80082, 3508 TB Utrecht, The Netherlands., de Vries A, Nijkamp FP, Engels F |
| المصدر: | European journal of pharmacology [Eur J Pharmacol] 2005 Jul 25; Vol. 518 (1), pp. 77-8. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print Cited Medium: Print ISSN: 0014-2999 (Print) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : Amsterdam : Elsevier Science Original Publication: Amsterdam, North Holland Pub. Co. |
| مواضيع طبية MeSH: | Allergens/*pharmacology , Capsaicin/*analogs & derivatives , Muscle Contraction/*drug effects , Receptors, Drug/*antagonists & inhibitors , Trachea/*drug effects, Animals ; Capsaicin/pharmacology ; Guinea Pigs ; In Vitro Techniques ; Male ; Ovalbumin/pharmacology ; Receptors, Drug/physiology ; Trachea/physiology |
| مستخلص: | To investigate the possible role of the vanilloid receptor-1 (TRPV1) in allergic airway responses, the effect of the specific TRPV1 receptor antagonist capsazepine was examined. Capsazepine significantly decreased the ovalbumin-induced contraction of isolated tracheal rings from ovalbumin-sensitized guinea pigs. This is the first report directly showing the involvement of the TRPV1 in experimental allergic airway responses. |
| المشرفين على المادة: | 0 (Allergens) 0 (Receptors, Drug) 9006-59-1 (Ovalbumin) LFW48MY844 (capsazepine) S07O44R1ZM (Capsaicin) |
| تواريخ الأحداث: | Date Created: 20050706 Date Completed: 20050923 Latest Revision: 20141120 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.ejphar.2005.06.003 |
| PMID: | 15996655 |
| قاعدة البيانات: | MEDLINE |
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