Independent and additive impact of blood pressure control and angiotensin II receptor blockade on renal outcomes in the irbesartan diabetic nephropathy trial: clinical implications and limitations.

التفاصيل البيبلوغرافية
العنوان:	Independent and additive impact of blood pressure control and angiotensin II receptor blockade on renal outcomes in the irbesartan diabetic nephropathy trial: clinical implications and limitations.
المؤلفون:	Pohl MA; Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A51, Cleveland, OH 44195, USA. pohlm@ccf.org, Blumenthal S, Cordonnier DJ, De Alvaro F, Deferrari G, Eisner G, Esmatjes E, Gilbert RE, Hunsicker LG, de Faria JB, Mangili R, Moore J Jr, Reisin E, Ritz E, Schernthaner G, Spitalewitz S, Tindall H, Rodby RA, Lewis EJ
المصدر:	Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2005 Oct; Vol. 16 (10), pp. 3027-37. Date of Electronic Publication: 2005 Aug 24.
نوع المنشور:	Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: Wolters Kluwer Health, on behalf of the American Society of Nephrology Country of Publication: United States NLM ID: 9013836 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1046-6673 (Print) Linking ISSN: 10466673 NLM ISO Abbreviation: J Am Soc Nephrol Subsets: MEDLINE
أسماء مطبوعة:	Publication: 2023- : Hagerstown, MD : Wolters Kluwer Health, on behalf of the American Society of Nephrology Original Publication: Baltimore, MD : Williams & Wilkins, c1990-
مواضيع طبية MeSH:	Amlodipine/therapeutic use , Angiotensin II Type 1 Receptor Blockers/therapeutic use , Antihypertensive Agents/therapeutic use , Biphenyl Compounds/therapeutic use , Diabetic Nephropathies/drug therapy , Hypertension/drug therapy , Tetrazoles/*therapeutic use, Diabetic Nephropathies/complications ; Double-Blind Method ; Follow-Up Studies ; Humans ; Hypertension/complications ; Irbesartan
مستخلص:	Elevated arterial pressure is a major risk factor for progression to ESRD in diabetic nephropathy. However, the component of arterial pressure and level of BP control for optimal renal outcomes are disputed. Data from 1590 hypertensive patients with type 2 diabetes in the Irbesartan Diabetic Nephropathy Trial (IDNT), a randomized, double-blind, placebo-controlled trial performed in 209 clinics worldwide, were examined, and the effects of baseline and mean follow-up systolic BP (SBP) and diastolic BP and the interaction of assigned study medications (irbesartan, amlodipine, and placebo) on progressive renal failure and all-cause mortality were assessed. Other antihypertensive agents were added to achieve predetermined BP goals. Entry criteria included elevated baseline serum creatinine concentration up to 266 micromol/L (3.0 mg/dl) and urine protein excretion >900 mg/d. Baseline BP averaged 159/87 +/- 20/11 mmHg. Median patient follow-up was 2.6 yr. Follow-up achieved SBP most strongly predicted renal outcomes. SBP >149 mmHg was associated with a 2.2-fold increase in the risk for doubling serum creatinine or ESRD compared with SBP <134 mmHg. Progressive lowering of SBP to 120 mmHg was associated with improved renal and patient survival, an effect independent of baseline renal function. Below this threshold, all-cause mortality increased. An additional renoprotective effect of irbesartan, independent of achieved SBP, was observed down to 120 mmHg. There was no correlation between diastolic BP and renal outcomes. We recommend a SBP target between 120 and 130 mmHg, in conjunction with blockade of the renin-angiotensin system, in patients with type 2 diabetic nephropathy.
المشرفين على المادة:	0 (Angiotensin II Type 1 Receptor Blockers) 0 (Antihypertensive Agents) 0 (Biphenyl Compounds) 0 (Tetrazoles) 1J444QC288 (Amlodipine) J0E2756Z7N (Irbesartan)
تواريخ الأحداث:	Date Created: 20050827 Date Completed: 20060330 Latest Revision: 20181201
رمز التحديث:	20240829
DOI:	10.1681/ASN.2004110919
PMID:	16120823
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1046-6673
DOI:	10.1681/ASN.2004110919