دورية أكاديمية
Frequency of beryllium-specific, central memory CD4+ T cells in blood determines proliferative response.
العنوان: | Frequency of beryllium-specific, central memory CD4+ T cells in blood determines proliferative response. |
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المؤلفون: | Fontenot AP; Division of Clinical Immunology, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA. andrew.fontenot@uchsc.edu, Palmer BE, Sullivan AK, Joslin FG, Wilson CC, Maier LA, Newman LS, Kotzin BL |
المصدر: | The Journal of clinical investigation [J Clin Invest] 2005 Oct; Vol. 115 (10), pp. 2886-93. Date of Electronic Publication: 2005 Sep 08. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
اللغة: | English |
بيانات الدورية: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0021-9738 (Print) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 1999- : Ann Arbor, MI : American Society for Clinical Investigation Original Publication: New Haven [etc.] American Society for Clinical Investigation. |
مواضيع طبية MeSH: | Berylliosis/*immunology , Beryllium/*pharmacology , CD4-Positive T-Lymphocytes/*immunology , Immunologic Memory/*drug effects , Lymphocyte Activation/*drug effects , T-Lymphocyte Subsets/*immunology, Aged ; Berylliosis/blood ; Beryllium/immunology ; Cell Proliferation/drug effects ; Cells, Cultured ; Chronic Disease ; Female ; Humans ; Immunologic Memory/immunology ; Lung/immunology ; Lung/pathology ; Lymphocyte Activation/immunology ; Male ; Middle Aged |
مستخلص: | Beryllium exposure can lead to the development of beryllium-specific CD4+ T cells and chronic beryllium disease (CBD), which is characterized by the presence of lung granulomas and a CD4+ T cell alveolitis. Studies have documented the presence of proliferating and cytokine-secreting CD4+ T cells in blood of CBD patients after beryllium stimulation. However, some patients were noted to have cytokine-secreting CD4 T cells in blood in the absence of beryllium-induced proliferation, and overall, the correlation between the 2 types of responses was poor. We hypothesized that the relative proportion of memory T cell subsets determined antigen-specific proliferation. In most CBD patients, the majority of beryllium-specific CD4+ T cells in blood expressed an effector memory T cell maturation phenotype. However, the ability of blood cells to proliferate in the presence of beryllium strongly correlated with the fraction expressing a central memory T cell phenotype. In addition, we found a direct correlation between the percentage of beryllium-specific CD4+ T(EM) cells in blood and T cell lymphocytosis in the lung. Together, these findings indicate that the functional capability of antigen-specific CD4+ T cells is determined by the relative proportion of memory T cell subsets, which may reflect internal organ involvement. |
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معلومات مُعتمدة: | P01 ES011810 United States ES NIEHS NIH HHS; ES06358 United States ES NIEHS NIH HHS; ES011810 United States ES NIEHS NIH HHS; HL62410 United States HL NHLBI NIH HHS; R01 HL062410 United States HL NHLBI NIH HHS; M01-RR-0051 United States RR NCRR NIH HHS; M01 RR000051 United States RR NCRR NIH HHS |
المشرفين على المادة: | OW5102UV6N (Beryllium) |
تواريخ الأحداث: | Date Created: 20050910 Date Completed: 20051212 Latest Revision: 20181113 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC1199530 |
DOI: | 10.1172/JCI24908 |
PMID: | 16151531 |
قاعدة البيانات: | MEDLINE |
تدمد: | 0021-9738 |
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DOI: | 10.1172/JCI24908 |