دورية أكاديمية
A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy.
| العنوان: | A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy. |
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| المؤلفون: | Ma Y; Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA., Hof PR, Grant SC, Blackband SJ, Bennett R, Slatest L, McGuigan MD, Benveniste H |
| المصدر: | Neuroscience [Neuroscience] 2005; Vol. 135 (4), pp. 1203-15. Date of Electronic Publication: 2005 Sep 13. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0306-4522 (Print) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [New York?] : Elsevier Science Original Publication: Oxford, Elmsford, N. Y., Pergamon Press |
| مواضيع طبية MeSH: | Anatomy, Artistic*/methods , Databases, Factual* , Magnetic Resonance Imaging* , Medical Illustration*, Brain/*anatomy & histology , Mice, Inbred C57BL/*anatomy & histology, Animals ; Imaging, Three-Dimensional ; Mice |
| مستخلص: | A comprehensive three-dimensional digital atlas database of the C57BL/6J mouse brain was developed based on magnetic resonance microscopy images acquired on a 17.6-T superconducting magnet. By using both manual tracing and an atlas-based semi-automatic segmentation approach, T2-weighted magnetic resonance microscopy images of 10 adult male formalin-fixed, excised C57BL/6J mouse brains were segmented into 20 anatomical structures. These structures included the neocortex, hippocampus, amygdala, olfactory bulbs, basal forebrain and septum, caudate-putamen, globus pallidus, thalamus, hypothalamus, central gray, superior colliculi, inferior colliculi, the rest of midbrain, cerebellum, brainstem, corpus callosum/external capsule, internal capsule, anterior commissure, fimbria, and ventricles. The segmentation data were formatted and stored into a database containing three different atlas types: 10 single-specimen brain atlases, an average brain atlas and a probabilistic atlas. Additionally, quantitative group information, such as variations in structural volume, surface area, magnetic resonance microscopy image intensity and local geometry, were computed and stored as an integral part of the database. The database augments ongoing efforts with other high priority strains as defined by the Mouse Phenome Database focused on providing a quantitative framework for accurate mapping of functional, genetic and protein expression patterns acquired by a myriad of technologies and imaging modalities. |
| معلومات مُعتمدة: | P41 RR16105 United States RR NCRR NIH HHS; R01 EB 00233-04 United States EB NIBIB NIH HHS |
| تواريخ الأحداث: | Date Created: 20050917 Date Completed: 20060111 Latest Revision: 20220330 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.neuroscience.2005.07.014 |
| PMID: | 16165303 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0306-4522 |
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| DOI: | 10.1016/j.neuroscience.2005.07.014 |