دورية أكاديمية
Abrogation of delayed type hypersensitivity response to Candida albicans produced by a molecular mimic of phosphorylated prolactin.
| العنوان: | Abrogation of delayed type hypersensitivity response to Candida albicans produced by a molecular mimic of phosphorylated prolactin. |
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| المؤلفون: | Guzmán EA; The University of Texas-Houston, Graduate School of Biomedical Sciences, Houston Texas 77030, USA., Chen YH, Langowski JL, De Guzman A, Lo HL, Walter B, Muller HK, Walker AM, Owen LB |
| المصدر: | Journal of neuroimmunology [J Neuroimmunol] 2005 Dec 30; Vol. 170 (1-2), pp. 31-40. Date of Electronic Publication: 2005 Sep 19. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 8109498 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0165-5728 (Print) Linking ISSN: 01655728 NLM ISO Abbreviation: J Neuroimmunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Amsterdam] : Elsevier/North-Holland, c1981- |
| مواضيع طبية MeSH: | Molecular Mimicry* , Phosphorylation*, Candida albicans/*immunology , Hypersensitivity, Delayed/*immunology , Prolactin/*metabolism , Prolactin/*pharmacology, Animals ; Antibodies, Fungal/immunology ; Antibody Formation/drug effects ; Apoptosis/drug effects ; Cytokines/antagonists & inhibitors ; Fas Ligand Protein ; Hypersensitivity, Delayed/physiopathology ; Immunoglobulin G/metabolism ; Inflammation Mediators/antagonists & inhibitors ; Lymph Nodes/metabolism ; Male ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Inbred Strains ; Spleen/pathology ; Spleen/physiopathology ; Tumor Necrosis Factors/metabolism |
| مستخلص: | The effects of two major forms of prolactin (PRL) were examined on delayed type hypersensitivity (DTH) responses to Candida albicans. Unmodified PRL (U-PRL) had no effect on the DTH response, whereas a molecular mimic of phosphorylated PRL (S179D PRL) significantly inhibited immune responses to this robust antigen. This effect of S179D PRL was not accompanied by gross alterations in splenic T cell numbers, CD4/CD8 ratios, or T and B cell activation markers, but did produce a decrease in splenocyte apoptosis. Using gld animals, Fas ligand (FasL) was implicated in the suppressive effects of S179D PRL. Circulating IgG1 and IgG2 antibody levels were increased in response to treatment with both forms of PRL, but the effects of S179D PRL were most pronounced. Cytokine changes in the popliteal lymph nodes specific to S179D PRL treatment showed an inhibition of pro-inflammatory cytokines. In conclusion, mice treated with a molecular mimic of phosphorylated prolactin showed a profound inhibition of DTH responses to Candida correlating with an absence of GM-CSF, IL-4, and IL-13 production and a marked reduction in IL-12p70 synthesis. |
| معلومات مُعتمدة: | R01 DK061005 United States DK NIDDK NIH HHS; DK 61005 United States DK NIDDK NIH HHS; R01CA52457 United States CA NCI NIH HHS |
| المشرفين على المادة: | 0 (Antibodies, Fungal) 0 (Cytokines) 0 (Fas Ligand Protein) 0 (Fasl protein, mouse) 0 (Immunoglobulin G) 0 (Inflammation Mediators) 0 (Membrane Glycoproteins) 0 (Tumor Necrosis Factors) 9002-62-4 (Prolactin) |
| تواريخ الأحداث: | Date Created: 20050920 Date Completed: 20060214 Latest Revision: 20161019 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jneuroim.2005.08.009 |
| PMID: | 16169603 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0165-5728 |
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| DOI: | 10.1016/j.jneuroim.2005.08.009 |