دورية أكاديمية
[Effect of tamoxifen in lipids of diabetic rats induced by streptozotocin].
| العنوان: | [Effect of tamoxifen in lipids of diabetic rats induced by streptozotocin]. |
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| عنوان ترانسليتريتد: | Efeito do tamoxifeno no perfil lipídico de ratos diabéticos por estreptozotocina. |
| المؤلفون: | Nogueira Júnior FC; Farmacêutico Bioquímica Graduado pela UFRN, Natal - RN, Brasil., Coelho DA, Almeida MM, Silva TC, Ferreira EC, Macedo UB, Neto FP, Brandão Neto J, Almeida Md, de Rezende AA |
| المصدر: | Acta cirurgica brasileira [Acta Cir Bras] 2005; Vol. 20 Suppl 1, pp. 114-20. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Portuguese |
| بيانات الدورية: | Publisher: Sociedade Brasileira Para O Desenvolvimento Da Pesquisa Em Cirurgia Curso De Pos-Graduacao Em Tecnica Operatoria E Cirurgia Experimental Escola Paulista De Medicina Country of Publication: Brazil NLM ID: 9103983 Publication Model: Print Cited Medium: Print ISSN: 0102-8650 (Print) Linking ISSN: 01028650 NLM ISO Abbreviation: Acta Cir Bras Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Sao Paulo : Sociedade Brasileira Para O Desenvolvimento Da Pesquisa Em Cirurgia Curso De Pos-Graduacao Em Tecnica Operatoria E Cirurgia Experimental Escola Paulista De Medicina Original Publication: São Paulo : A Sociedade, |
| مواضيع طبية MeSH: | Cholesterol/*blood , Diabetes Mellitus, Experimental/*drug therapy , Estrogen Antagonists/*therapeutic use , Lipid Metabolism/*drug effects , Tamoxifen/*therapeutic use , Triglycerides/*blood, Albumins/analysis ; Animals ; Creatinine/blood ; Diabetes Mellitus, Experimental/blood ; Female ; Proteins/analysis ; Rats ; Rats, Wistar ; Streptozocin ; Urea/blood |
| مستخلص: | Objective: To evaluate the effect of tamoxifen in the lipidic and renal profile in diabetic and control rats. Methods: 40 female Wistar rats had been used (180-220g corporal weight), divided randomly in 4 groups: C (n = 10, received vehicle), T (n = 10, treated with tamoxifen, 0.3mg/kg/day), D (n = 10, diabetic induced by streptozotocin, 45mg/Kg) and DT (n = 10, diabetic treated with tamoxifen). Glucose, total cholesterol, triglyceride, total proteins, albumin, urea and creatinin were analyzed using Labtest Kits through the Cobas Mira analyzer (Germany, 1996). Results: Group T presented a reduction of total cholesterol and triglyceride in relation to C, and group D an increase in relation to the other ones. About the total proteins it was observed an increasing in Group T in relation to C. The albumin diminished in groups D and DT in relation to C and T. The urea levels increased in groups D and DT in relation to C and T. Conclusion: In relation to the lipidic profile it was evidenced that during the period of 60 days the treatment with tamoxifen promoted a reduction in cholesterol and triglyceride levels in the serum, even associated to the condition of Diabetes mellitus. |
| المشرفين على المادة: | 0 (Albumins) 0 (Estrogen Antagonists) 0 (Proteins) 0 (Triglycerides) 094ZI81Y45 (Tamoxifen) 5W494URQ81 (Streptozocin) 8W8T17847W (Urea) 97C5T2UQ7J (Cholesterol) AYI8EX34EU (Creatinine) |
| تواريخ الأحداث: | Date Created: 20050928 Date Completed: 20071217 Latest Revision: 20161020 |
| رمز التحديث: | 20231215 |
| DOI: | /S0102-86502005000700013 |
| PMID: | 16186978 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0102-8650 |
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| DOI: | /S0102-86502005000700013 |