دورية أكاديمية
Membrane mechanisms of antiarrhythmic effect of quaternidine.
| العنوان: | Membrane mechanisms of antiarrhythmic effect of quaternidine. |
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| المؤلفون: | Balashov VP; Department of Medical Biology, N. P. Ogarev Mordovian State University, Saransk, Russia. byp63@yandex.ru, Blinov DS, Kazachenko VN, Astashev ME, Agenosova OG |
| المصدر: | Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2005 Jun; Vol. 139 (6), pp. 688-91. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print Cited Medium: Print ISSN: 0007-4888 (Print) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Springer Original Publication: New York, Consultants Bureau. |
| مواضيع طبية MeSH: | Anti-Arrhythmia Agents/*classification , Anti-Arrhythmia Agents/*pharmacology , Membrane Potentials/*drug effects , Quaternary Ammonium Compounds/*pharmacology , Trimecaine/*analogs & derivatives, Action Potentials/drug effects ; Animals ; Cats ; Electrocardiography ; Electrodes ; Electrophysiology ; Heart Atria/drug effects ; Heart Conduction System/drug effects ; Heart Ventricles/drug effects ; Neurons/drug effects ; Papillary Muscles/drug effects ; Patch-Clamp Techniques ; Rats ; Snails ; Trimecaine/pharmacology |
| مستخلص: | Complex electrophysiological study of the effects of quaternidine carried out on intact hearts from cats, myocardial fragments from rats, and single ionic channels of large edible snail showed that quaternidine demonstrates properties of class 1B antiarrhythmic drug according to Vaughan-Williams nomenclature. This agent did not suppress nomotopic pacemaker automaticity, did not change conduction in ventricles, atria, and atrioventricular junction in hearts with preserved sinus rhythm, did not prolong refractoriness of the atria and atrioventricular junction, but prolonged efficient refractory period of heart ventricles. Quaternidine decelerated rapid depolarization of the action potential, but had no effect on its duration. It did not affect potassium conductance. |
| المشرفين على المادة: | 0 (Anti-Arrhythmia Agents) 0 (Quaternary Ammonium Compounds) 0 (quaternidine) IN1233R0JO (Trimecaine) |
| تواريخ الأحداث: | Date Created: 20051015 Date Completed: 20060216 Latest Revision: 20190813 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1007/s10517-005-0379-y |
| PMID: | 16224582 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 0007-4888 |
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| DOI: | 10.1007/s10517-005-0379-y |