دورية أكاديمية
أعرض في EDS

Adenovirus infection and cytotoxicity of primary mantle cell lymphoma cells.

التفاصيل البيبلوغرافية
العنوان: Adenovirus infection and cytotoxicity of primary mantle cell lymphoma cells.
المؤلفون: Medina DJ; The Cancer Institute of New Jersey, Department of Medicine, Biomedical Center, Lund University, Lund, Sweden. medinadj@umdnj.edu, Sheay W, Osman M, Goodell L, Martin J, Rabson AB, Strair RK
المصدر: Experimental hematology [Exp Hematol] 2005 Nov; Vol. 33 (11), pp. 1337-47.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Inc Country of Publication: Netherlands NLM ID: 0402313 Publication Model: Print Cited Medium: Print ISSN: 0301-472X (Print) Linking ISSN: 0301472X NLM ISO Abbreviation: Exp Hematol Subsets: MEDLINE
أسماء مطبوعة: Publication: 1999- : Amsterdam : Elsevier Science Inc.
Original Publication: Copenhagen, Munksgaard.
مواضيع طبية MeSH: Adenoviridae Infections*, Adenoviridae/*pathogenicity , Biological Therapy/*methods , Lymphoma, Mantle-Cell/*therapy, Adenoviridae/genetics ; Adenovirus E1A Proteins/genetics ; Adenovirus E1B Proteins/deficiency ; Adenovirus E1B Proteins/genetics ; Cell Death ; Humans ; Lymphoma, Mantle-Cell/pathology ; Mutation ; Vaccines, Attenuated/pharmacology ; Virulence/genetics
مستخلص: Mantle cell lymphoma (MCL) is a distinct form of non-Hodgkin's lymphoma (NHL) derived from CD5+ B cells. MCL cells overexpress cyclin D1 as a consequence of translocation of the gene into the immunoglobulin heavy-chain gene locus. MCL is an aggressive form of NHL with frequent relapses after standard-dose chemotherapy. In this context, a variety of novel therapies for patients with MCL have been investigated. In this study, we use an expanded panel of attenuated adenoviruses to study adenovirus-mediated cytotoxicity of MCL cells. Our results demonstrate: 1) adenovirus infection of MCL cells despite the absence of receptor/coreceptor molecules known to be important for adenovirus infection of other cells types; 2) cytotoxicity of MCL cells after infection with specific adenovirus mutants; 3) a high degree of cytotoxicity after infection of some patient samples with viruses lacking the E1B 19k "antiapoptotic" gene; and 4) cytotoxicity after infection with viruses containing mutations in E1A pRb or p300 binding. The extent of cytotoxicity with the panel of viruses demonstrated interpatient variability, but 100% cytotoxicity, as determined by molecular analysis, was detected in some samples. These studies provide the foundation for: 1) the development of adenoviruses as cytotoxic agents for MCL and 2) analyses of key regulatory pathways operative in MCL cells.
المشرفين على المادة: 0 (Adenovirus E1A Proteins)
0 (Adenovirus E1B Proteins)
0 (Vaccines, Attenuated)
تواريخ الأحداث: Date Created: 20051103 Date Completed: 20060112 Latest Revision: 20061115
رمز التحديث: 20240628
DOI: 10.1016/j.exphem.2005.07.009
PMID: 16263418
قاعدة البيانات: MEDLINE
الوصف
تدمد:0301-472X
DOI:10.1016/j.exphem.2005.07.009