دورية أكاديمية
Heart rate characteristics: novel physiomarkers to predict neonatal infection and death.
| العنوان: | Heart rate characteristics: novel physiomarkers to predict neonatal infection and death. |
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| المؤلفون: | Griffin MP; Department of Pediatrics, University of Virginia Health System, Charlottesville, Virginia, USA., Lake DE, Bissonette EA, Harrell FE Jr, O'Shea TM, Moorman JR |
| المصدر: | Pediatrics [Pediatrics] 2005 Nov; Vol. 116 (5), pp. 1070-4. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Academy of Pediatrics Country of Publication: United States NLM ID: 0376422 Publication Model: Print Cited Medium: Internet ISSN: 1098-4275 (Electronic) Linking ISSN: 00314005 NLM ISO Abbreviation: Pediatrics Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Elk Grove Village Il : American Academy of Pediatrics Original Publication: Springfield, Ill., Thomas. |
| مواضيع طبية MeSH: | Heart Rate*, Infant, Premature, Diseases/*diagnosis , Sepsis/*diagnosis , Urinary Tract Infections/*diagnosis, Gestational Age ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases/mortality ; Infant, Very Low Birth Weight ; Monitoring, Physiologic ; Sepsis/mortality ; Sepsis/physiopathology ; Survival Rate ; Urinary Tract Infections/mortality ; Urinary Tract Infections/physiopathology |
| مستخلص: | Objective: Monitoring of regulated physiologic processes using physiomarkers such as heart rate variability may be important in the early diagnosis of subacute, potentially catastrophic illness. Early in the course of neonatal sepsis, there are physiomarkers of reduced heart rate variability and transient decelerations similar to fetal distress. The goal of this study was to determine the degree of increased risk for sepsis, urinary tract infection (UTI), and death when these abnormal heart rate characteristics (HRC) were observed. Methods: We monitored 1022 infants at 2 tertiary care NICUs, 458 of whom were very low birth weight. We calculated an HRC index from validated regression models relating mathematical features of heart rate time series and histograms to episodes of illness. We calculated the risks for adverse events of sepsis, UTI, and death for infants stratified by HRC measurements. Results: Compared with infants with low-risk HRC measurements, infants with high-risk HRC measurements had 5- to 6-fold increased risk for an adverse event in the next day and 3-fold increased risk in the next week. Laboratory tests that were relevant to infection added information to HRC measurements. Infants with both high-risk HRC and abnormal laboratory tests had 6- to 7-fold increased risk for an adverse event in the next day compared with infants who had neither. Conclusion: HRC are noninvasively monitored physiomarkers that identify infants in the NICU who are at high risk for sepsis, UTI, and death. |
| التعليقات: | Comment in: Pediatrics. 2006 May;117(5):1853-4; author reply 1854. (PMID: 16651352) |
| معلومات مُعتمدة: | 64640 United States PHS HHS |
| تواريخ الأحداث: | Date Created: 20051103 Date Completed: 20051228 Latest Revision: 20071114 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1542/peds.2004-2461 |
| PMID: | 16263991 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1098-4275 |
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| DOI: | 10.1542/peds.2004-2461 |