دورية أكاديمية
The vervet monkey (Chlorocebus aethiops) as an experimental model for Trypanosoma brucei gambiense human African trypanosomiasis: a clinical, biological and pathological study.
| العنوان: | The vervet monkey (Chlorocebus aethiops) as an experimental model for Trypanosoma brucei gambiense human African trypanosomiasis: a clinical, biological and pathological study. |
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| المؤلفون: | Ouwe-Missi-Oukem-Boyer O; Centre de Recherche Médicale et Sanitaire (CERMES), BP 10887, Niamey, Niger. o.oukem@cirmf.org, Mezui-Me-Ndong J, Boda C, Lamine I, Labrousse F, Bisser S, Bouteille B |
| المصدر: | Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 2006 May; Vol. 100 (5), pp. 427-36. Date of Electronic Publication: 2005 Dec 01. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 7506129 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0035-9203 (Print) Linking ISSN: 00359203 NLM ISO Abbreviation: Trans R Soc Trop Med Hyg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2013- : Oxford : Oxford University Press Original Publication: 1920- : London : Royal Society of Tropical Medicine and Hygiene |
| مواضيع طبية MeSH: | Chlorocebus aethiops* , Disease Models, Animal* , Models, Animal* , Trypanosoma brucei gambiense* , Trypanosomiasis, African*/blood , Trypanosomiasis, African*/cerebrospinal fluid , Trypanosomiasis, African*/transmission, Animals ; Antibodies, Protozoan/blood ; Brain/parasitology ; Female ; Hemoglobins/analysis ; Humans ; Immunohistochemistry/methods ; Male ; Parasitemia |
| مستخلص: | It has long been known that the vervet monkey, Chlorocebus (C.) aethiops, can be infected with Trypanosoma rhodesiense, but this model has not been described for T. gambiense. In this study, we report the development of such a model for human African trypanosomiasis. Twelve vervet monkeys infected with T. gambiense developed chronic disease. The duration of the disease ranged between 23 and 612 days (median 89 days) in five untreated animals. Trypanosomes were detected in the blood within the first 10 days post-infection and in the cerebrospinal fluid, with a median delay of 120 days (n = 4, range 28-348 days). Clinical changes included loss of weight, adenopathy, and in some cases eyelid oedema and lethargy. Haematological alterations included decreases in haemoglobin level and transitory decreases in platelet count. Biological modifications included increased gamma globulins and total proteins and decreased albumin. Pathological features of the infection were presence of Mott's cells, inflammatory infiltration of either mononuclear cells or lymphocytes and plasma cells in the brain parenchyma, and astrocytosis. These observations indicate that the development of the disease in vervet monkeys is similar to human T. gambiense infection. We conclude that C. aethiops is a promising experimental primate model for the study of T. gambiense trypanosomiasis. |
| المشرفين على المادة: | 0 (Antibodies, Protozoan) 0 (Hemoglobins) |
| تواريخ الأحداث: | Date Created: 20051206 Date Completed: 20060824 Latest Revision: 20191210 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.trstmh.2005.07.023 |
| PMID: | 16325877 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0035-9203 |
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| DOI: | 10.1016/j.trstmh.2005.07.023 |