دورية أكاديمية
In vitro activity of Phytolacca dodecandra (Endod) against dermatophytes.
| العنوان: | In vitro activity of Phytolacca dodecandra (Endod) against dermatophytes. |
|---|---|
| المؤلفون: | Woldeamanuel Y; Department of Microbiology, Immunology and Parasitology, Tikur Anbessa Hospital, P.O. Box 9086, Addis Ababa, Ethiopia., Abate G, Chryssanthou E |
| المصدر: | Ethiopian medical journal [Ethiop Med J] 2005 Jan; Vol. 43 (1), pp. 31-4. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Ethiopian Medical Association Country of Publication: Ethiopia NLM ID: 0373223 Publication Model: Print Cited Medium: Print ISSN: 0014-1755 (Print) Linking ISSN: 00141755 NLM ISO Abbreviation: Ethiop Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Addis Ababa : Ethiopian Medical Association |
| مواضيع طبية MeSH: | Phytolacca dodecandra*, Antifungal Agents/*pharmacology , Arthrodermataceae/*drug effects , Plant Preparations/*pharmacology, Disease Susceptibility ; Humans ; In Vitro Techniques ; Microbial Sensitivity Tests |
| مستخلص: | There is a need for better and less costly treatment of superficial mycotic infections, and one approach might be testing of'traditionally used plants for their antifungal activities as potentials for drug development. The aim of the present study was to determine the in vitro activity of Phytolacca dodecandra (Endod) on various species of dermatophytes and yeasts of medical importance. The aqueous extract from the plant P. dodecandra was tested for its antifungal activity against 33 dermatophyte and yeast strains. The minimum inhibitory concentration (MIC) was determined by adopting the broth microdilution method for testing of conidium forming filamentous fungi according to the NCCLS M38-P proposed standard with some modifications. The MIC of P. dodecandra against the dermatophytes tested ranged from 19.5 mg/l to 156.0 mg/l, while for all the yeasts the MIC was >500 mg/l. The minimum inhibitory concentration for 50% (MIC50) of the dermatophyte strains was 62.5 mg/l. The extract showed fungicidal activity against the dermatophytes that ranged from 19.5 to 312.5 mg/l. No activity was observed against the yeasts. From our preliminary results antifungal activity of P. dodecandra has been shown. This should he strengthened with more extensive studies which address both the antifungal activity and the active principle that is responsible for its fungicidal activity. |
| المشرفين على المادة: | 0 (Antifungal Agents) 0 (Plant Preparations) |
| تواريخ الأحداث: | Date Created: 20051224 Date Completed: 20060201 Latest Revision: 20141120 |
| رمز التحديث: | 20240628 |
| PMID: | 16370528 |
| قاعدة البيانات: | MEDLINE |
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