دورية أكاديمية
Effects of experimental increases and decreases in thyroxine levels on the extent of cataleptic freezing reactions in rats.
| العنوان: | Effects of experimental increases and decreases in thyroxine levels on the extent of cataleptic freezing reactions in rats. |
|---|---|
| المؤلفون: | Kulikov AV; Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, 10 Lavrent'ev Prospekt, 630090 Novosibirsk, Russia., Tikhonova MA, Lebedeva EI, Chugui VF, Popova NK |
| المصدر: | Neuroscience and behavioral physiology [Neurosci Behav Physiol] 2005 Sep; Vol. 35 (7), pp. 763-7. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 0330471 Publication Model: Print Cited Medium: Print ISSN: 0097-0549 (Print) Linking ISSN: 00970549 NLM ISO Abbreviation: Neurosci Behav Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005- > : New York : Springer Original Publication: Washington, Scripta Pub. Corp. |
| مواضيع طبية MeSH: | Freezing Reaction, Cataleptic/*physiology , Hyperthyroxinemia/*physiopathology , Thyroxine/*blood, Animals ; Antithyroid Agents/administration & dosage ; Behavior, Animal ; Drug Administration Schedule ; Freezing Reaction, Cataleptic/drug effects ; Male ; Methimazole/pharmacology ; Propylthiouracil/administration & dosage ; Rats ; Rats, Wistar ; Thyroid Hormones/pharmacology ; Thyroxine/administration & dosage ; Time Factors |
| مستخلص: | Numerous clinical observations have provided evidence for a tight connection between impairments in the functions of the hypothalamo-hypophyseal-thyroid system and nervous and mental disorders. The aim of the present work was to compare the effects of experimental decreases and increases in blood thyroxine levels on the extents of two types of pathological freezing reaction in male Wistar rats--spontaneous catalepsy and catalepsy evoked by pinches at the nape of the neck (pinch-induced catalepsy). Chronic administration of the thyroxine synthesis inhibitor propylthiouracil (5 mg/kg/day for 28 days) significantly decreased the blood hormone level and sharply increased the proportion of animals showing spontaneous catalepsy and the immobility time, but had no effect on the extent of pinch-induced catalepsy. At the same time, chronic administration of thyroxine (0.1 mg/kg/day for 28 days), which produced significant increases in blood hormone levels, had no effect on the extent of spontaneous catalepsy but significantly increased the proportion of animals showing pinch-induced catalepsy and the duration of this type of catalepsy. It is concluded that both insufficiency and excess of thyroid hormones have cataleptogenic actions, but enhance different types of catalepsy. |
| References: | Neurosci Biobehav Rev. 1996 Summer;20(2):325-39. (PMID: 8811720) Am J Med Genet. 1995 Jun 19;60(3):214-20. (PMID: 7573174) Behav Genet. 1993 Jul;23(4):379-84. (PMID: 8240217) Prog Neurobiol. 1989;32(5):403-22. (PMID: 2567528) Clin Endocrinol (Oxf). 1995 Dec;43(6):713-9. (PMID: 8736274) Thyroid. 1996 Oct;6(5):537-43. (PMID: 8936685) Neurosci Lett. 1993 Oct 29;161(2):223-6. (PMID: 7903803) Physiol Behav. 2002 Apr 15;75(5):733-7. (PMID: 12020738) Behav Neurosci. 1988 Oct;102(5):748-59. (PMID: 2904271) Endocrinology. 1996 Jun;137(6):2490-502. (PMID: 8641203) Eur J Endocrinol. 1998 Jan;138(1):1-9. (PMID: 9461307) Neurosci Lett. 2002 Sep 20;330(2):207-9. (PMID: 12231448) Biol Psychiatry. 1979 Feb;14(1):111-7. (PMID: 420894) Ann Clin Psychiatry. 1994 Dec;6(4):259-66. (PMID: 7647836) Br J Med Psychol. 1998 Dec;71 ( Pt 4):417-45. (PMID: 9875954) Br J Psychiatry Suppl. 1996 Jun;(30):123-8. (PMID: 8864158) Neuropsychopharmacology. 2001 Jun;24(6):632-9. (PMID: 11331143) Neuroendocrinology. 1996 Jul;64(1):65-9. (PMID: 8811668) |
| المشرفين على المادة: | 0 (Antithyroid Agents) 0 (Thyroid Hormones) 554Z48XN5E (Methimazole) 721M9407IY (Propylthiouracil) Q51BO43MG4 (Thyroxine) |
| تواريخ الأحداث: | Date Created: 20060126 Date Completed: 20060302 Latest Revision: 20190902 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s11055-005-0121-2 |
| PMID: | 16433073 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder كن أول من يترك تعليقا!