دورية أكاديمية
Successful treatment with etanercept in a patient with hepatotoxicity closely related to infliximab.
| العنوان: | Successful treatment with etanercept in a patient with hepatotoxicity closely related to infliximab. |
|---|---|
| المؤلفون: | García Aparicio AM; Rheumatology Unit, Hospital Virgen de la Salud, Toledo, Spain. angel_apa@hotmail.com, Rey JR, Sanz AH, Alvarez JS |
| المصدر: | Clinical rheumatology [Clin Rheumatol] 2007 May; Vol. 26 (5), pp. 811-3. Date of Electronic Publication: 2006 Jul 07. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Germany NLM ID: 8211469 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0770-3198 (Print) Linking ISSN: 07703198 NLM ISO Abbreviation: Clin Rheumatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2008->: Heidelberg : Springer Original Publication: Brussels : Acta Medica Belgica, [1982- |
| مواضيع طبية MeSH: | Antibodies, Monoclonal/*adverse effects , Antirheumatic Agents/*adverse effects , Chemical and Drug Induced Liver Injury/*etiology , Immunoglobulin G/*therapeutic use , Receptors, Tumor Necrosis Factor/*therapeutic use , Spondylarthropathies/*drug therapy, Etanercept ; Humans ; Infliximab ; Male ; Middle Aged |
| مستخلص: | To date, hepatotoxicity with anti-TNF therapy has been associated with concomitant liver-toxicity drugs, infection or malignant diseases. We report the case of one patient with spondyloarthropathty who presented severe liver dysfunction related to infliximab. After the second infusion serum controls showed an slightly increase of transaminases. Before the administration of fifth infusion, infliximab therapy was stopped due to severe liver damage (AST 327 mU/ml, ALT 656 mU/mL, GGT 140 mU/mL, alkaline phosphate 227 mU/mL). Ten weeks after infliximab discontinuation serum concentrations of liver blood tests were normal but ankylosing spondylitis symptoms had relapsed. Therefore, he was treated with etanercept with a rapid and sustained improvement. Serum concentrations of albumin, AST, ALT, GGT and alkaline phosphate were followed and did not change for five months. |
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| المشرفين على المادة: | 0 (Antibodies, Monoclonal) 0 (Antirheumatic Agents) 0 (Immunoglobulin G) 0 (Receptors, Tumor Necrosis Factor) B72HH48FLU (Infliximab) OP401G7OJC (Etanercept) |
| تواريخ الأحداث: | Date Created: 20060322 Date Completed: 20070626 Latest Revision: 20181113 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s10067-006-0253-y |
| PMID: | 16550301 |
| قاعدة البيانات: | MEDLINE |
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