دورية أكاديمية
أعرض في EDS

Levels of serum chemokines discriminate clinical myelopathy associated with human T lymphotropic virus type 1 (HTLV-1)/tropical spastic paraparesis (HAM/TSP) disease from HTLV-1 carrier state.

التفاصيل البيبلوغرافية
العنوان: Levels of serum chemokines discriminate clinical myelopathy associated with human T lymphotropic virus type 1 (HTLV-1)/tropical spastic paraparesis (HAM/TSP) disease from HTLV-1 carrier state.
المؤلفون: Guerreiro JB; Serviço de Imunologia, Hospital Universitário Prof Edgard Santos, Universidade Federal da Bahia, 5o andar, Rua João das Botas s/n Canela, 40110-160 Salvador, Bahia, Brazil., Santos SB, Morgan DJ, Porto AF, Muniz AL, Ho JL, Teixeira AL Jr, Teixeira MM, Carvalho EM
المصدر: Clinical and experimental immunology [Clin Exp Immunol] 2006 Aug; Vol. 145 (2), pp. 296-301.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0057202 Publication Model: Print Cited Medium: Print ISSN: 0009-9104 (Print) Linking ISSN: 00099104 NLM ISO Abbreviation: Clin Exp Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2022- : Oxford : Oxford University Press
Original Publication: Oxford : Blackwell Scientific Publications
مواضيع طبية MeSH: Human T-lymphotropic virus 1*, Chemokines/*blood , Paraparesis, Tropical Spastic/*diagnosis, Biomarkers/blood ; Carrier State/diagnosis ; Carrier State/immunology ; Case-Control Studies ; Chemokine CCL11 ; Chemokine CCL2/blood ; Chemokine CCL24 ; Chemokine CXCL10 ; Chemokine CXCL9 ; Chemokines, CC/blood ; Chemokines, CXC/blood ; Diagnosis, Differential ; Enzyme-Linked Immunosorbent Assay ; Humans ; Interferon-gamma/blood ; Interleukin-8 ; Paraparesis, Tropical Spastic/immunology ; Statistics, Nonparametric
مستخلص: Approximately 5% of people infected with human T lymphotropic virus type 1 (HTLV-1) develop clinical myelopathy or tropical spastic paraparesis (HAM/TSP) that is associated with high-levels of Th1 cytokines, interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha. Chemokines are known to induce cytokine secretion and direct the trafficking of immune cells to sites of disease. The present study measured serum chemokines correlated with autonomously released IFN-gamma in cell cultures. HTLV-1 infection was defined by enzyme-linked immunosorbent assay (ELISA) and confirmed by Western blot. Subjects included HTLV-1 carriers (n = 56), patients with HAM/TSP (n = 31) and healthy HTLV-1 seronegative volunteer controls (n = 20). Serum chemokines and IFN-gamma autonomously released by mononuclear cells in culture were quantified by ELISA. Compared to HTLV-1 carriers, serum chemokines in HAM/TSP patients showed significantly increased levels of CXCL9 and CXCL10, significantly diminished levels of CCL2 and similar amounts of CCL11 and CCL24. In contrast, CCL11 and CCL24 were significantly lower in serum of HAM/TSP patients than either control. IFN-gamma was positively correlated with CXCL9 and CXCL10 when HAM/TSP and HTLV-1 carriers were used as a combined group. However, despite a large proportion of HTLV-1 carriers having high IFN-gamma levels, these chemokines were not increased in carriers. This study showed that high levels of CXCL9 and CXCL10 in the systemic circulation and low serum CCL2 levels are features of HAM/TSP. HTLV-1 infection and Tax and/or additional viral encoded factor-mediated pathological processes triggering T cell activation with autogenous IFN-gamma release are probably involved in regulating chemokine release.
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معلومات مُعتمدة: T32 AI007613 United States AI NIAID NIH HHS; R03 AI 060830 United States AI NIAID NIH HHS; D43 TW 007127 United States TW FIC NIH HHS; R03 AI060830 United States AI NIAID NIH HHS; T32 AI 07613 United States AI NIAID NIH HHS; D43 TW007127 United States TW FIC NIH HHS
المشرفين على المادة: 0 (Biomarkers)
0 (CCL11 protein, human)
0 (CCL24 protein, human)
0 (CXCL8 protein, human)
0 (CXCL9 protein, human)
0 (Chemokine CCL11)
0 (Chemokine CCL2)
0 (Chemokine CCL24)
0 (Chemokine CXCL10)
0 (Chemokine CXCL9)
0 (Chemokines)
0 (Chemokines, CC)
0 (Chemokines, CXC)
0 (Interleukin-8)
82115-62-6 (Interferon-gamma)
تواريخ الأحداث: Date Created: 20060802 Date Completed: 20060921 Latest Revision: 20220228
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC1809672
DOI: 10.1111/j.1365-2249.2006.03150.x
PMID: 16879249
قاعدة البيانات: MEDLINE
الوصف
تدمد:0009-9104
DOI:10.1111/j.1365-2249.2006.03150.x