دورية أكاديمية
Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells.
| العنوان: | Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells. |
|---|---|
| المؤلفون: | Stowell SR; Department of Biochemistry and Molecular Biology, Oklahoma Center for Medical Glycobiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Karmakar S, Stowell CJ, Dias-Baruffi M, McEver RP, Cummings RD |
| المصدر: | Blood [Blood] 2007 Jan 01; Vol. 109 (1), pp. 219-27. Date of Electronic Publication: 2006 Aug 29. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0006-4971 (Print) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [New York] : Elsevier Original Publication: New York, Grune & Stratton [etc.] |
| مواضيع طبية MeSH: | Galectin 1/*pharmacology , Galectin 2/*pharmacology , Galectin 4/*pharmacology , Membrane Lipids/*metabolism , Neutrophils/*metabolism , Phosphatidylserines/*metabolism , T-Lymphocytes/*metabolism, Apoptosis ; Cell Line, Tumor/cytology ; Cell Line, Tumor/drug effects ; Cells, Cultured/cytology ; Cells, Cultured/drug effects ; Dithiothreitol/pharmacology ; Galectin 1/physiology ; Galectin 2/physiology ; Galectin 4/physiology ; HL-60 Cells/cytology ; HL-60 Cells/drug effects ; HL-60 Cells/metabolism ; Humans ; Lymphocyte Activation ; N-Formylmethionine Leucyl-Phenylalanine/pharmacology ; Neutrophils/drug effects ; Neutrophils/immunology ; Organ Specificity ; Oxidation-Reduction ; Recombinant Fusion Proteins/pharmacology ; Respiratory Burst ; Surface Properties ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology |
| مستخلص: | Cellular turnover is associated with exposure of surface phosphatidylserine (PS) in apoptotic cells, leading to their phagocytic recognition and removal. But recent studies indicate that surface PS exposure is not always associated with apoptosis. Here we show that several members of the human galectin family of glycan binding proteins (galectins-1, -2, and -4) induce PS exposure in a carbohydrate-dependent fashion in activated, but not resting, human neutrophils and in several leukocyte cell lines. PS exposure is not associated with apoptosis in activated neutrophils. The exposure of PS in cell lines treated with these galectins is sustained and does not affect cell viability. Unexpectedly, these galectins bind well to activated T lymphocytes, but do not induce either PS exposure or apoptosis, indicating that galectin's effects are cell specific. These results suggest novel immunoregulatory contribution of galectins in regulating leukocyte turnover independently of apoptosis. |
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| معلومات مُعتمدة: | RR15577 United States RR NCRR NIH HHS; T32 GM008169 United States GM NIGMS NIH HHS; HL34363 United States HL NHLBI NIH HHS; R37 HL034363 United States HL NHLBI NIH HHS; P20 RR015577 United States RR NCRR NIH HHS; HL085607 United States HL NHLBI NIH HHS; P01 HL085607 United States HL NHLBI NIH HHS; R01 HL034363 United States HL NHLBI NIH HHS |
| المشرفين على المادة: | 0 (Galectin 1) 0 (Galectin 2) 0 (Galectin 4) 0 (LGALS1 protein, human) 0 (Membrane Lipids) 0 (Phosphatidylserines) 0 (Recombinant Fusion Proteins) 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine) T8ID5YZU6Y (Dithiothreitol) |
| تواريخ الأحداث: | Date Created: 20060831 Date Completed: 20070220 Latest Revision: 20210206 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC1785076 |
| DOI: | 10.1182/blood-2006-03-007153 |
| PMID: | 16940423 |
| قاعدة البيانات: | MEDLINE |
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