دورية أكاديمية
Differential activation of the JNK signal pathway by UV irradiation and glucose deprivation.
| العنوان: | Differential activation of the JNK signal pathway by UV irradiation and glucose deprivation. |
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| المؤلفون: | Song JJ; Department of Surgery and Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA., Lee YJ |
| المصدر: | Cellular signalling [Cell Signal] 2007 Mar; Vol. 19 (3), pp. 563-72. Date of Electronic Publication: 2006 Aug 30. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0898-6568 (Print) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Ltd Original Publication: Oxford ; New York : Pergamon Press, 1988- |
| مواضيع طبية MeSH: | Ultraviolet Rays*, Adenocarcinoma/*pathology , Glucose/*deficiency , JNK Mitogen-Activated Protein Kinases/*metabolism , Signal Transduction/*physiology , Signal Transduction/*radiation effects, Cell Line, Tumor ; Humans ; Male ; Models, Biological ; Prostatic Neoplasms/pathology |
| مستخلص: | Exposure of mammalian cells to ultraviolet (UV) light or glucose deprivation activates c-Jun NH2-terminal protein kinase (JNK). However, the exact mechanism by which UV induces JNK activation is not yet understood completely. Previously, we have observed that glucose deprivation activates the ASK1-SEK1-JNK signal transduction pathway. In the present study, we reveal that UVC irradiation-induced JNK activation has a different signal transduction pathway from glucose deprivation. UVC irradiation increases the interaction between JIP3 and MEKK1, SEK1, while glucose deprivation increases the interaction between JIP3 and ASK1, SEK1, and JNK. UVC irradiation activates MEKK1 rather than ASK1. We also observed that MEKK1 interacted with Grb2 and Grb2-MEKK1 complex was recruited to epidermal growth factor receptor (EGFR) after UVC irradiation. Taken together, our data demonstrate that UVC-induced JNK activation adopts a different signaling cascade (EGFR-Grb2-MEKK1-SEK1-JNK) from glucose deprivation (ASK1-SEK1-JNK). |
| معلومات مُعتمدة: | CA121395 United States CA NCI NIH HHS; CA95191 United States CA NCI NIH HHS; CA96989 United States CA NCI NIH HHS |
| المشرفين على المادة: | EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases) IY9XDZ35W2 (Glucose) |
| تواريخ الأحداث: | Date Created: 20061013 Date Completed: 20070420 Latest Revision: 20131121 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.cellsig.2006.08.016 |
| PMID: | 17029735 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0898-6568 |
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| DOI: | 10.1016/j.cellsig.2006.08.016 |