دورية أكاديمية
Targeting VEGF-A to treat cancer and age-related macular degeneration.
| العنوان: | Targeting VEGF-A to treat cancer and age-related macular degeneration. |
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| المؤلفون: | Ferrara N; Genentech, Inc., South San Francisco, California 94080, USA. nf@gene.com, Mass RD, Campa C, Kim R |
| المصدر: | Annual review of medicine [Annu Rev Med] 2007; Vol. 58, pp. 491-504. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Annual Reviews Country of Publication: United States NLM ID: 2985151R Publication Model: Print Cited Medium: Print ISSN: 0066-4219 (Print) Linking ISSN: 00664219 NLM ISO Abbreviation: Annu Rev Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Palo Alto Ca : Annual Reviews Original Publication: Palo Alto, Calif., Annual Reviews, inc. |
| مواضيع طبية MeSH: | Macular Degeneration/*drug therapy , Macular Degeneration/*etiology , Neoplasms/*drug therapy , Neoplasms/*etiology , Vascular Endothelial Growth Factor A/*antagonists & inhibitors , Vascular Endothelial Growth Factor A/*physiology, Angiogenesis Inhibitors/therapeutic use ; Humans |
| مستخلص: | Inhibiting angiogenesis is a promising strategy to treat cancer and several other disorders, including intraocular neovascular syndromes. The identification of vascular endothelial growth factor (VEGF)-A as a major regulator of normal and pathological angiogenesis has enabled significant progress toward effective treatments for such disorders. Several VEGF inhibitors have been recently approved by the U.S. Food and Drug Administration for the treatment of cancer and the neovascular form of age-related macular degeneration. This review summarizes the basic biology of VEGF-A and illustrates the clinical progress in targeting this molecule. |
| Number of References: | 100 |
| المشرفين على المادة: | 0 (Angiogenesis Inhibitors) 0 (VEGFA protein, human) 0 (Vascular Endothelial Growth Factor A) |
| تواريخ الأحداث: | Date Created: 20061021 Date Completed: 20070403 Latest Revision: 20220409 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1146/annurev.med.58.061705.145635 |
| PMID: | 17052163 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0066-4219 |
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| DOI: | 10.1146/annurev.med.58.061705.145635 |