دورية أكاديمية
A new paradigm for the regulation of the mammalian ribosomal RNA genes.
| العنوان: | A new paradigm for the regulation of the mammalian ribosomal RNA genes. |
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| المؤلفون: | Moss T; Cancer Research Centre and Department of Medical Biology, Laval University, CHUQ-HDQ, Pavillon St. Patrick, 9 rue McMahon, QC, Canada G1R 3S3. Tom.Moss@crhdq.ulaval.ca, Stefanovsky V, Langlois F, Gagnon-Kugler T |
| المصدر: | Biochemical Society transactions [Biochem Soc Trans] 2006 Dec; Vol. 34 (Pt 6), pp. 1079-81. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Portland Press On The Behalf Of The Biochemical Society Country of Publication: England NLM ID: 7506897 Publication Model: Print Cited Medium: Print ISSN: 0300-5127 (Print) Linking ISSN: 03005127 NLM ISO Abbreviation: Biochem Soc Trans Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Portland Press On The Behalf Of The Biochemical Society |
| مواضيع طبية MeSH: | RNA, Ribosomal/*genetics, Animals ; DNA-Directed RNA Polymerases/genetics ; Gene Expression Regulation ; Growth Substances/physiology ; Mammals ; Models, Genetic ; Models, Molecular ; RNA, Ribosomal/chemistry ; Transcription, Genetic |
| مستخلص: | Ribosome assembly occurs co-transcriptionally on the rRNA genes. This process requires the co-ordinated expression and assembly of many hundreds of proteins and is finely tuned to cell and organism growth. Co-ordinate regulation of the rRNA genes and the ribosomal protein genes is therefore essential for high-fidelity ribosome assembly. Recent work shows that rRNA gene transcription is regulated at the level of elongation via the mitogen-activated protein kinase pathway. We argue that this may provide an explanation for the high fidelity of ribosome assembly. |
| المشرفين على المادة: | 0 (Growth Substances) 0 (RNA, Ribosomal) EC 2.7.7.6 (DNA-Directed RNA Polymerases) |
| تواريخ الأحداث: | Date Created: 20061101 Date Completed: 20070213 Latest Revision: 20061031 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1042/BST0341079 |
| PMID: | 17073755 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0300-5127 |
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| DOI: | 10.1042/BST0341079 |