دورية أكاديمية
[Clinical characteristics of myasthenia gravis with dysphonia as the initial symptom].
| العنوان: | [Clinical characteristics of myasthenia gravis with dysphonia as the initial symptom]. |
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| المؤلفون: | Sun WH; Department of Otorhinolaryngology, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China. sunwh@qingdaonews.com, Liu HM, Liang DP, Wan XM, Cong ZQ, Wang HP |
| المصدر: | Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery [Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi] 2006 Sep; Vol. 41 (9), pp. 644-7. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhonghua yi xue hui za zhi she Country of Publication: China NLM ID: 101247574 Publication Model: Print Cited Medium: Print ISSN: 1673-0860 (Print) Linking ISSN: 16730860 NLM ISO Abbreviation: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Beijing : Zhonghua yi xue hui za zhi she, 2005- |
| مواضيع طبية MeSH: | Dysphonia/*etiology , Myasthenia Gravis/*complications , Myasthenia Gravis/*diagnosis, Adolescent ; Adult ; Age Distribution ; Diagnosis, Differential ; Dysphonia/diagnosis ; Female ; Humans ; Male ; Middle Aged ; Sex Distribution ; Young Adult |
| مستخلص: | Objective: To identify clinical features and diagnostic tests that would alert the otolaryngologist to consider myasthenia gravis (MG) in the differential diagnosis of dysphonia, we reviewed the clinical characteristics of MG whose initial symptom is dysphonia. Methods: 31 patients who presented with dysphonia as their initial and primary complaint are reported, their symptoms and signs are observed and analyzed. Results: Patients with dysphonia as their initial symptom of MG may complain of vocal fatigue, difficulty sustaining or projecting their voices, breathy voice or intermittent hoarseness. These symptoms are characterized by fluctuating weakness and abnormal fatigability. Flexible fibroendoscopic examination revealed that patients had incomplete adduction of the vocal folds, fatigue of the tensors of the vocal fold, incomplete glottic closure, vocal cord paralysis, saliva pooling over the bilateral or unilateral pyriform sinus. Neostigmine test revealed dramatic improvement in all patients. Serum levels of anti-Ach-R antibodies were tested in 19 cases, only 5 cases were abnormality. All patients had improved after treatment Conclusions: Voice changes can be the first sign of early MG. Based on fluctuating weakness or weak voice at the end of the day, a positive neostigmine test, significantly higher circulating antibody to acetylcholine receptor, a diagnosis of MG could definitively be made. |
| تواريخ الأحداث: | Date Created: 20061123 Date Completed: 20110519 Latest Revision: 20061120 |
| رمز التحديث: | 20231215 |
| PMID: | 17111801 |
| قاعدة البيانات: | MEDLINE |
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