دورية أكاديمية
Vascular targeted nanoparticles for imaging and treatment of brain tumors.
| العنوان: | Vascular targeted nanoparticles for imaging and treatment of brain tumors. |
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| المؤلفون: | Reddy GR; Molecular Therapeutics, Inc., Ann Arbor, MI 48109, USA., Bhojani MS, McConville P, Moody J, Moffat BA, Hall DE, Kim G, Koo YE, Woolliscroft MJ, Sugai JV, Johnson TD, Philbert MA, Kopelman R, Rehemtulla A, Ross BD |
| المصدر: | Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2006 Nov 15; Vol. 12 (22), pp. 6677-86. |
| نوع المنشور: | Evaluation Study; Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Print ISSN: 1078-0432 (Print) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Denville, NJ : The Association, c1995- |
| مواضيع طبية MeSH: | Brain Neoplasms/*diagnostic imaging , Brain Neoplasms/*therapy , Glioma/*diagnostic imaging , Glioma/*therapy , Nanoparticles/*therapeutic use , Photochemotherapy/*methods, Angiography/methods ; Animals ; Blood Vessels/drug effects ; Brain Neoplasms/blood supply ; Brain Neoplasms/mortality ; Diagnostic Imaging/methods ; Dihematoporphyrin Ether/administration & dosage ; Drug Administration Routes ; Drug Carriers/therapeutic use ; Ferric Compounds/administration & dosage ; Glioma/blood supply ; Glioma/mortality ; Humans ; Male ; Nanotechnology ; Photosensitizing Agents/administration & dosage ; Rats ; Survival Analysis ; Tumor Cells, Cultured |
| مستخلص: | Purpose: Development of new therapeutic drug delivery systems is an area of significant research interest. The ability to directly target a therapeutic agent to a tumor site would minimize systemic drug exposure, thus providing the potential for increasing the therapeutic index. Experimental Design: Photodynamic therapy (PDT) involves the uptake of a sensitizer by the cancer cells followed by photoirradiation to activate the sensitizer. PDT using Photofrin has certain disadvantages that include prolonged cutaneous photosensitization. Delivery of nanoparticles encapsulated with photodynamic agent specifically to a tumor site could potentially overcome the drawbacks of systemic therapy. In this study, we have developed a multifunctional polymeric nanoparticle consisting of a surface-localized tumor vasculature targeting F3 peptide and encapsulated PDT and imaging agents. Results: The nanoparticles specifically bound to the surface of MDA-435 cells in vitro and were internalized conferring photosensitivity to the cells. Significant magnetic resonance imaging contrast enhancement was achieved in i.c. rat 9L gliomas following i.v. nanoparticle administration. Serial magnetic resonance imaging was used for determination of pharmacokinetics and distribution of nanoparticles within the tumor. Treatment of glioma-bearing rats with targeted nanoparticles followed by PDT showed a significant improvement in survival rate when compared with animals who received PDT after administration of nontargeted nanoparticles or systemic Photofrin. Conclusions: This study reveals the versatility and efficacy of the multifunctional nanoparticle for the targeted detection and treatment of cancer. |
| معلومات مُعتمدة: | R24-CA83099 United States CA NCI NIH HHS; R24CA83099 United States CA NCI NIH HHS; P50CA93990 United States CA NCI NIH HHS; N01-CO-37123 United States CO NCI NIH HHS; R24 CA083099 United States CA NCI NIH HHS; P01CA85878 United States CA NCI NIH HHS; P50 CA093990 United States CA NCI NIH HHS |
| المشرفين على المادة: | 0 (Drug Carriers) 0 (Ferric Compounds) 0 (Photosensitizing Agents) 1K09F3G675 (ferric oxide) 97067-70-4 (Dihematoporphyrin Ether) |
| تواريخ الأحداث: | Date Created: 20061124 Date Completed: 20070206 Latest Revision: 20191210 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1158/1078-0432.CCR-06-0946 |
| PMID: | 17121886 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1078-0432 |
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| DOI: | 10.1158/1078-0432.CCR-06-0946 |