دورية أكاديمية
2,2,4-Trimethylpentane induces Ca2+ release from the sarcoplasmic reticulum terminal cisterns.
| العنوان: | 2,2,4-Trimethylpentane induces Ca2+ release from the sarcoplasmic reticulum terminal cisterns. |
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| المؤلفون: | Ritov VB; School of Biology, M.V. Lomonosov Moscow State University, U.S.S.R., Men'shikova EV |
| المصدر: | Biochimica et biophysica acta [Biochim Biophys Acta] 1991 Aug 26; Vol. 1067 (2), pp. 187-90. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Pub. Co Country of Publication: Netherlands NLM ID: 0217513 Publication Model: Print Cited Medium: Print ISSN: 0006-3002 (Print) Linking ISSN: 00063002 NLM ISO Abbreviation: Biochim Biophys Acta Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Pub. Co. |
| مواضيع طبية MeSH: | Calcium/*metabolism , Octanes/*pharmacology , Sarcoplasmic Reticulum/*drug effects, Adenosine Triphosphate/metabolism ; Aminoquinolines ; Animals ; Benzoylcholine/pharmacology ; Caffeine/pharmacology ; Cations, Divalent ; Fluorescent Dyes ; Hydrolysis ; In Vitro Techniques ; Magnesium/pharmacology ; Rabbits ; Ruthenium Red/pharmacology ; Sarcoplasmic Reticulum/metabolism ; Tetracaine/pharmacology |
| مستخلص: | Using quin2, the effects of aliphatic hydrocarbons on the system of Ca(2+)-induced Ca2+ release in isolated membranes of rabbit skeletal muscle terminal cisterns have been studied. The hydrocarbons were inserted into the membranes by means of hydrocarbon-containing liposomes. 2,2,4-Trimethylpentane (isooctane) caused a rapid release of 70-75% of Ca2+ taken up by the terminal cistern vesicles during the Ca(2+)-pump operation. This effect was inhibited by the caffeine-induced Ca2+ release blockers--Mg2+, ruthenium red and tetracaine. The same was observed with a decrease in the concentration of ATP that is known to activate the terminal cistern Ca2+ channels. The effect of 2,2,4-trimethylpentane on the longitudinal cistern fractions practically devoid of Ca(2+)-channels was insignificant. Heptane, hexane and octane caused a slow release of 5-10% of the accumulated Ca2+ from the terminal cistern vesicles; no such effect was induced by decane. |
| المشرفين على المادة: | 0 (Aminoquinolines) 0 (Cations, Divalent) 0 (Fluorescent Dyes) 0 (Octanes) 0619F35CGV (Tetracaine) 11103-72-3 (Ruthenium Red) 2208-04-0 (Benzoylcholine) 3G6A5W338E (Caffeine) 8L70Q75FXE (Adenosine Triphosphate) I38ZP9992A (Magnesium) O448IDK23O (Quin2) QAB8F5669O (2,2,4-trimethylpentane) SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 19910826 Date Completed: 19911003 Latest Revision: 20190609 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/0005-2736(91)90042-7 |
| PMID: | 1715188 |
| قاعدة البيانات: | MEDLINE |
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