دورية أكاديمية
أعرض في EDS

Selective septohippocampal - but not forebrain amygdalar - cholinergic dysfunction in diencephalic amnesia.

التفاصيل البيبلوغرافية
العنوان: Selective septohippocampal - but not forebrain amygdalar - cholinergic dysfunction in diencephalic amnesia.
المؤلفون: Savage LM; Behavioral Neuroscience Program, Department of Psychology, Binghamton University, State University of New York, Binghamton, NY 13902, USA. lsavage@binghamton.edu, Roland J, Klintsova A
المصدر: Brain research [Brain Res] 2007 Mar 30; Vol. 1139, pp. 210-9. Date of Electronic Publication: 2007 Jan 08.
نوع المنشور: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0006-8993 (Print) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Acetylcholine/*metabolism , Amnesia/*metabolism , Amygdala/*metabolism , Exploratory Behavior/*physiology , Hippocampus/*metabolism , Neural Pathways/*metabolism, Amnesia/etiology ; Analysis of Variance ; Animals ; Choline O-Acetyltransferase/metabolism ; Cholinergic Fibers/metabolism ; Discrimination Learning/physiology ; Disease Models, Animal ; Male ; Pyrithiamine ; Rats ; Rats, Sprague-Dawley ; Septum of Brain/metabolism ; Thiamine Deficiency/chemically induced ; Thiamine Deficiency/complications
مستخلص: A rodent model of diencephalic amnesia, pyrithiamine-induced thiamine deficiency (PTD), was used to investigate diencephalic-limbic interactions. In-vivo acetylcholine (ACh) efflux, a marker of memory-related activation, was measured in the hippocampus and the amygdala of PTD-treated and pair-fed (PF) control rats while they were tested on a spontaneous alternation task. During behavioral testing, all animals displayed increases in ACh efflux in both the hippocampus and amygdala. However, during spontaneous alternation testing ACh efflux in the hippocampus and the alternation scores were higher in PF rats relative to PTD-treated rats. In contrast, ACh efflux in the amygdala was not suppressed in PTD treated rats, relative to PF rats, prior to or during behavioral testing. In addition, unbiased stereological estimates of the number of choline acetyltransferase (ChAT) immunopositive neurons in the medial septal/diagonal band (MS/DB) and nucleus basalis of Meynert (NBM) also reveal a selective cholinergic dysfunction: In PTD-treated rats a significant loss of ChAT-immunopositive cells was found only in the MS/DB, but not in the NBM. Significantly, these results demonstrate that thiamine deficiency causes selective cholinergic dysfunction in the septo-hippocampal pathway.
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معلومات مُعتمدة: R01 NS054272 United States NS NINDS NIH HHS; 054272 United States PHS HHS
المشرفين على المادة: 5JB3029BJ7 (Pyrithiamine)
EC 2.3.1.6 (Choline O-Acetyltransferase)
N9YNS0M02X (Acetylcholine)
تواريخ الأحداث: Date Created: 20070210 Date Completed: 20070508 Latest Revision: 20181113
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC1868479
DOI: 10.1016/j.brainres.2006.12.083
PMID: 17289001
قاعدة البيانات: MEDLINE
الوصف
تدمد:0006-8993
DOI:10.1016/j.brainres.2006.12.083