دورية أكاديمية
The rates of chemotherapy-induced amenorrhea in patients treated with adjuvant doxorubicin and cyclophosphamide followed by a taxane.
| العنوان: | The rates of chemotherapy-induced amenorrhea in patients treated with adjuvant doxorubicin and cyclophosphamide followed by a taxane. |
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| المؤلفون: | Tham YL; Breast Care Center, The Methodist Hospital and Baylor College of Medicine, Houston, Texas, USA. yltham@breastcenter.tmc.edu, Sexton K, Weiss H, Elledge R, Friedman LC, Kramer R |
| المصدر: | American journal of clinical oncology [Am J Clin Oncol] 2007 Apr; Vol. 30 (2), pp. 126-32. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8207754 Publication Model: Print Cited Medium: Internet ISSN: 1537-453X (Electronic) Linking ISSN: 02773732 NLM ISO Abbreviation: Am J Clin Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: New York, N.Y. : Masson Pub. USA, c1982- |
| مواضيع طبية MeSH: | Amenorrhea/*chemically induced , Antineoplastic Combined Chemotherapy Protocols/*adverse effects , Breast Neoplasms/*drug therapy, Adult ; Amenorrhea/epidemiology ; Cyclophosphamide/administration & dosage ; Doxorubicin/administration & dosage ; Drug Administration Schedule ; Female ; Humans ; Middle Aged ; Parity ; Pregnancy ; Premenopause ; Retrospective Studies ; Socioeconomic Factors ; Surveys and Questionnaires ; Taxoids/administration & dosage |
| مستخلص: | Objective: Adjuvant chemotherapy in premenopausal women with breast cancer may induce amenorrhea, which can affect fertility, choice of hormonal therapy, and increase the risk of late toxicity. The incidence of chemotherapy-induced amenorrhea (CIA) resulting from doxorubicin and cyclophosphamide (AC) followed by a taxane (T) is poorly characterized. Methods: We retrospectively surveyed women who were premenopausal and less than age 50 at initiation of chemotherapy to determine the rates of CIA in women receiving AC followed by T compared with AC alone. Results: One hundred ninety-one eligible women completed the survey. The rate of CIA in women who received AC followed by T was 64% (95% confidence interval [CI] = 55-72%) compared with 55% (95% CI = 43-66%) in AC alone. As expected, CIA rates were higher in older than younger women (82% vs. 55%, P = 0.004). Multivariate logistic regression analysis revealed that age >40 was associated with a 4.6-fold increased risk of CIA (95% CI = 1.7-12.1, P = 0.002). It also revealed that receiving T after AC was associated with an odds ratio of 1.9 for CIA as compared with receiving AC alone (95% CI = 1.0-3.5, P = 0.05). Despite > or =6 months of amenorrhea, many women < or =40 resumed menses (40%). CIA was more likely to be irreversible in those >40. The addition of taxanes did not alter the rate of reversibility for the group as a whole (P = 0.36). Conclusions: Older age and the addition of taxane to AC increased the risk of CIA and the amenorrhea was more likely to be irreversible for women >40. Women < or =40 often resume menstruation even after 6 months of amenorrhea, and the addition of T does not play a role. Subsequent resumption of menstrual function must be considered when initiating appropriate hormonal therapy. |
| المشرفين على المادة: | 0 (Taxoids) 80168379AG (Doxorubicin) 8N3DW7272P (Cyclophosphamide) |
| تواريخ الأحداث: | Date Created: 20070407 Date Completed: 20070427 Latest Revision: 20151119 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1097/01.coc.0000251398.57630.4f |
| PMID: | 17414460 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-453X |
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| DOI: | 10.1097/01.coc.0000251398.57630.4f |