دورية أكاديمية
How is the biocompatibilty of dental biomaterials evaluated?
| العنوان: | How is the biocompatibilty of dental biomaterials evaluated? |
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| المؤلفون: | Murray PE; College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, FL 33328-2018, USA. petemur@nova.edu, García Godoy C, García Godoy F |
| المصدر: | Medicina oral, patologia oral y cirugia bucal [Med Oral Patol Oral Cir Bucal] 2007 May 01; Vol. 12 (3), pp. E258-66. Date of Electronic Publication: 2007 May 01. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medicina Oral S.L Country of Publication: Spain NLM ID: 101231694 Publication Model: Electronic Cited Medium: Internet ISSN: 1698-6946 (Electronic) Linking ISSN: 16984447 NLM ISO Abbreviation: Med Oral Patol Oral Cir Bucal Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Valencia, España : Medicina Oral S.L., [2004]- |
| مواضيع طبية MeSH: | Biocompatible Materials/*standards , Dental Materials/*standards , Guidelines as Topic/*standards , Materials Testing/*methods, Animals ; Humans ; Materials Testing/standards |
| مستخلص: | All biomaterials used in dentistry must be evaluated for biocompatibility using screening assays to protect patient health and safety. The purpose of this review is to explain the international biocompatibility guidelines, and to explain the structure of a test program. The test program requires the structured assessment of materials into four phases; general toxicity, local tissue irritation, pre-clinical, and clinical evaluation. Different types of screening assays are available, and it is important to understand the advantages and limitations of the various types of assays that are available, so that they can be selected for appropriateness and interpreted accurately. New scientific advances in terms of the chemical properties of dental materials, tissue engineering, stem cell, genetic transfer, biomaterial, and growth factor therapies are under development. These new therapies create improved opportunities to restore and regenerate oral tissues, but they can also present new hazards to patients. Prior to their clinical use, these new technologies must be proven to be safe, and not hazardous to human health. A structured biocompatibility assessment and advice on the selection of assays are outlined to evaluate these new therapies. |
| Number of References: | 86 |
| المشرفين على المادة: | 0 (Biocompatible Materials) 0 (Dental Materials) |
| تواريخ الأحداث: | Date Created: 20070501 Date Completed: 20070514 Latest Revision: 20091211 |
| رمز التحديث: | 20221213 |
| PMID: | 17468726 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1698-6946 |
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