دورية أكاديمية
The expression of Bcl-2 family proteins and spontaneous apoptosis in laryngeal carcinomas.
| العنوان: | The expression of Bcl-2 family proteins and spontaneous apoptosis in laryngeal carcinomas. |
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| المؤلفون: | Chen GG; Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong. gchen@cuhk.edu.hk, Vlantis AC, Chak EC, Liu HC, Tong MC, van Hasselt CA |
| المصدر: | Oncology research [Oncol Res] 2006; Vol. 16 (6), pp. 273-80. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Tech Science Press Country of Publication: United States NLM ID: 9208097 Publication Model: Print Cited Medium: Print ISSN: 0965-0407 (Print) Linking ISSN: 09650407 NLM ISO Abbreviation: Oncol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : Henderson, NV : Tech Science Press Original Publication: New York : Pergamon Press, c1992- |
| مواضيع طبية MeSH: | Apoptosis*, Carcinoma, Squamous Cell/*chemistry , Laryngeal Neoplasms/*chemistry , Proto-Oncogene Proteins c-bcl-2/*analysis, Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/physiopathology ; Cell Differentiation ; Female ; Humans ; Immunohistochemistry ; In Situ Nick-End Labeling ; Laryngeal Neoplasms/pathology ; Laryngeal Neoplasms/physiopathology ; Male ; Middle Aged ; bcl-2 Homologous Antagonist-Killer Protein/analysis ; bcl-2-Associated X Protein/analysis |
| مستخلص: | Bcl-2 family proteins play an important role in the growth and biological behavior of tumors. This study aimed to determine Bcl-2 family proteins in laryngeal carcinoma and to examine their relationship with spontaneous apoptosis. The material studied was from 39 patients with laryngeal carcinoma. It was found that the expression of both Bak and Bax was lower in tumor tissues than in nontumor tissues. However, there was no difference in the expression of Bcl-2 between tumor and nontumor tissues. The frequency of spontaneous apoptosis was lower in tumor tissues than in nontumor tissues but was not significantly related to the expression of Bak, Bax, or Bcl-2. Bak was decreased in moderately differentiated tumors compared to well-differentiated tumors. In contrast to Bak, the expression of Bcl-2 was increased in moderately differentiated tumors compared to well-differentiated tumors. These results indicate that the reduction in Bak may be associated with an increase in tumor grade and dedifferentiation in laryngeal carcinomas. The lack of correlation between apoptosis and the expression of Bcl-2 family proteins suggests that spontaneous apoptosis in laryngeal carcinoma is a complex process and that molecules other than Bak, Bax, and Bcl-2 participate in it. |
| المشرفين على المادة: | 0 (BAK1 protein, human) 0 (BAX protein, human) 0 (Proto-Oncogene Proteins c-bcl-2) 0 (bcl-2 Homologous Antagonist-Killer Protein) 0 (bcl-2-Associated X Protein) |
| تواريخ الأحداث: | Date Created: 20070505 Date Completed: 20070531 Latest Revision: 20191110 |
| رمز التحديث: | 20231215 |
| DOI: | 10.3727/000000006783981044 |
| PMID: | 17476972 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0965-0407 |
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| DOI: | 10.3727/000000006783981044 |