دورية أكاديمية
High-sensitivity C-reactive protein is quite low in Japanese men at high coronary risk.
| العنوان: | High-sensitivity C-reactive protein is quite low in Japanese men at high coronary risk. |
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| المؤلفون: | Matsushita K; Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsusumai, Showa-ku, Nagoya 466-8550, Japan., Yatsuya H, Tamakoshi K, Yang PO, Otsuka R, Wada K, Mitsuhashi H, Hotta Y, Kondo T, Murohara T, Toyoshima H |
| المصدر: | Circulation journal : official journal of the Japanese Circulation Society [Circ J] 2007 Jun; Vol. 71 (6), pp. 820-5. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Japanese Circulation Society Country of Publication: Japan NLM ID: 101137683 Publication Model: Print Cited Medium: Print ISSN: 1346-9843 (Print) Linking ISSN: 13469843 NLM ISO Abbreviation: Circ J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kyoto, Japan : Japanese Circulation Society, [2002- |
| مواضيع طبية MeSH: | C-Reactive Protein/*analysis , Coronary Disease/*blood, Adult ; Aged ; Asian People ; Coronary Disease/epidemiology ; Cross-Sectional Studies ; Humans ; Japan ; Male ; Middle Aged ; Predictive Value of Tests ; Risk Assessment ; Risk Factors |
| مستخلص: | Background: Although numerous studies have demonstrated a positive association of high-sensitivity C-reactive protein (CRP) with the incidence of coronary heart disease (CHD), little information exists regarding this issue in Japanese. Methods and Results: The association between CRP and the Framingham Risk Score (FRS) was investigated in 2,523 middle-aged Japanese men without a medical history of CHD. CRP was significantly associated with this score obtained from all FRS factors. After dividing subjects into 4 categories of relative risk estimate for CHD, the geometric mean of CRP (mg/L) increased gradually with the CHD risk (below average: 0.39 [95% confidence interval, 0.37-0.41], average: 0.58 [0.50-0.67], moderately above average: 0.70 [0.57-0.86], high: 0.79 [0.58-1.09], trend p<0.001). However, it should be noted that the mean CRP concentration of the high-risk group was only 0.79 mg/L and a greater proportion (63.8%) of the high-risk subjects was in the low-risk range of CRP (<1 mg/L). Conclusions: Circulating CRP well reflect the estimated CHD risk, indicating that CRP may be useful for coronary risk stratification in Japanese also. However, the details of the CRP level in Japanese must be investigated further by prospective studies to determine the Japanese-specific cutoff points for CHD risk evaluation. |
| التعليقات: | Comment in: Circ J. 2007 Sep;71(9):1501; author reply 1502. (PMID: 17721038) |
| المشرفين على المادة: | 9007-41-4 (C-Reactive Protein) |
| تواريخ الأحداث: | Date Created: 20070529 Date Completed: 20071212 Latest Revision: 20221207 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1253/circj.71.820 |
| PMID: | 17526975 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1346-9843 |
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| DOI: | 10.1253/circj.71.820 |