دورية أكاديمية
[2-year complete remission after withdrawal of methotrexate in a rectal methotrexate-associated diffuse large B-cell lymphoma].
| العنوان: | [2-year complete remission after withdrawal of methotrexate in a rectal methotrexate-associated diffuse large B-cell lymphoma]. |
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| المؤلفون: | Ogasawara T; Department of Medicine, Tokyo Women's Medical University Medical Center East., Kimura A, Yasuyama M, Ohtuka K, Aiba M, Kawauchi K |
| المصدر: | [Rinsho ketsueki] The Japanese journal of clinical hematology [Rinsho Ketsueki] 2007 Jun; Vol. 48 (6), pp. 485-90. |
| نوع المنشور: | Case Reports; English Abstract; Journal Article |
| اللغة: | Japanese |
| بيانات الدورية: | Publisher: Japan Society Of Clinical Hematology Country of Publication: Japan NLM ID: 2984782R Publication Model: Print Cited Medium: Print ISSN: 0485-1439 (Print) Linking ISSN: 04851439 NLM ISO Abbreviation: Rinsho Ketsueki Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Tokyo : Japan Society Of Clinical Hematology Original Publication: Tokyo, Rinsho Ketsueki Kondankai. |
| مواضيع طبية MeSH: | Antirheumatic Agents/*adverse effects , Lymphoma, B-Cell/*etiology , Lymphoma, Large B-Cell, Diffuse/*etiology , Lymphoproliferative Disorders/*etiology , Methotrexate/*adverse effects , Rectal Neoplasms/*etiology, Aged ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/drug therapy ; Epstein-Barr Virus Infections/complications ; Gene Rearrangement ; Genes, Immunoglobulin Heavy Chain/genetics ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/pathogenicity ; Humans ; Immunocompromised Host ; Male ; Remission Induction ; Time Factors |
| مستخلص: | A 71-year-old man, who had been receiving methotrexate (MTX) and prednisolone for the treatment of rheumatoid arthritis, was admitted to our hospital in August of 2004 with rectal hemorrhage. Histological examination of an ulcerative lesion of the rectum revealed diffuse large B-cell lymphoma (DLBCL). Chemotherapy with the CHOP regimen with dose reduction following cessation of MTX was initiated. However, the patient experienced septic shock secondary to febrile neutropenia and was then followed up without chemotherapy. The DLBCL rectal lesion regressed spontaneously thereafter and had resolved completely without treatment 2 years after the initial presentation, suggesting that the withdrawal of MTX led to regression of the DLBCL. The DLBCL in our patient is compatible with MTX-associated lymphoproliferative disorders. Immunoglobulin gene rearrangement and Epstein-Barr virus (EBV) infection found in tumor cells indicated that the EBV was involved in the monoclonal proliferation of B-cells in this patient whose immune function was suppressed by MTX therapy. |
| المشرفين على المادة: | 0 (Antirheumatic Agents) YL5FZ2Y5U1 (Methotrexate) |
| تواريخ الأحداث: | Date Created: 20070718 Date Completed: 20070828 Latest Revision: 20131121 |
| رمز التحديث: | 20240628 |
| PMID: | 17633096 |
| قاعدة البيانات: | MEDLINE |
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