دورية أكاديمية
Antiproliferative effect of panaxynol on RASMCs via inhibition of ERK1/2 and CREB.
| العنوان: | Antiproliferative effect of panaxynol on RASMCs via inhibition of ERK1/2 and CREB. |
|---|---|
| المؤلفون: | Jiang LP; Department of Pharmacy, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China., Lu Y, Nie BM, Chen HZ |
| المصدر: | Chemico-biological interactions [Chem Biol Interact] 2008 Feb 15; Vol. 171 (3), pp. 348-54. Date of Electronic Publication: 2007 Dec 08. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0009-2797 (Print) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Original Publication: Amsterdam, Elsevier. |
| مواضيع طبية MeSH: | CREB-Binding Protein/*antagonists & inhibitors , Cell Proliferation/*drug effects , Diynes/*pharmacology , Fatty Alcohols/*pharmacology , Mitogen-Activated Protein Kinase 1/*antagonists & inhibitors , Mitogen-Activated Protein Kinase 3/*antagonists & inhibitors , Muscle, Smooth, Vascular/*drug effects, Animals ; Aorta/cytology ; CREB-Binding Protein/biosynthesis ; Cell Cycle/drug effects ; Cells, Cultured ; DNA/biosynthesis ; DNA/drug effects ; Diynes/chemistry ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Fatty Alcohols/chemistry ; Mitogen-Activated Protein Kinase 1/biosynthesis ; Mitogen-Activated Protein Kinase 3/biosynthesis ; Molecular Conformation ; Muscle, Smooth, Vascular/cytology ; Muscle, Smooth, Vascular/metabolism ; Phosphorylation/drug effects ; Rats ; Signal Transduction/drug effects ; Time Factors |
| مستخلص: | Panaxynol (PNN) occurs in many foods such as carrot, celery, and several reports have shown that it has neuritogenic and neuroprotective properties. In this study, we have investigated the antiproliferative effect and the mechanism of PNN on platelet-derived growth factor (PDGF)-BB-induced proliferation of rat aortic vascular smooth muscle cells (RASMCs). PNN significantly inhibited PDGF-BB-induced proliferation and DNA synthesis of RASMCs in a concentration-dependent manner. Flow cytometry analysis showed that PNN blocked the cell cycle progression at the G(1)/S phase. Preincubation of RASMCs with 9 microM PNN resulted in a significant inhibition of PDGF-BB-induced extracellular signal-regulated kinase1/2 (ERK1/2) phosphorylation expression and PDGF-BB-induced CREB phosphorylation expression. The results indicated that the inhibitory effect of PNN on the PDGF-BB-induced proliferation of RASMCs might be mediated by blocking phosphorylation of ERK1/2 and that of CREB. |
| المشرفين على المادة: | 0 (Diynes) 0 (Fatty Alcohols) 21852-80-2 (falcarinol) 9007-49-2 (DNA) EC 2.3.1.48 (CREB-Binding Protein) EC 2.3.1.48 (Crebbp protein, rat) EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1) EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3) |
| تواريخ الأحداث: | Date Created: 20080118 Date Completed: 20080519 Latest Revision: 20161124 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.cbi.2007.11.013 |
| PMID: | 18199429 |
| قاعدة البيانات: | MEDLINE |
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