دورية أكاديمية
Correlations of long-term matrix metalloproteinase localization in human corneas after successful laser-assisted in situ keratomileusis with minor complications at the flap margin.
| العنوان: | Correlations of long-term matrix metalloproteinase localization in human corneas after successful laser-assisted in situ keratomileusis with minor complications at the flap margin. |
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| المؤلفون: | Fournié PR; Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, 1638 NW 10th Ave, Miami, FL 33136, USA. efini@med.miami.edu, Gordon GM, Dawson DG, Edelhauser HF, Fini ME |
| المصدر: | Archives of ophthalmology (Chicago, Ill. : 1960) [Arch Ophthalmol] 2008 Feb; Vol. 126 (2), pp. 162-70. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Medical Association Country of Publication: United States NLM ID: 7706534 Publication Model: Print Cited Medium: Print ISSN: 0003-9950 (Print) Linking ISSN: 00039950 NLM ISO Abbreviation: Arch Ophthalmol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Chicago, IL : American Medical Association |
| مواضيع طبية MeSH: | Keratomileusis, Laser In Situ* , Postoperative Complications* , Surgical Flaps*, Cornea/*enzymology , Cornea/*surgery , Matrix Metalloproteinases/*metabolism, Adult ; Fluorescent Antibody Technique, Indirect ; Follow-Up Studies ; Humans ; Middle Aged ; Wound Healing/physiology |
| مستخلص: | Objective: To determine whether matrix metalloproteinases (MMPs) are present long-term in human corneas after successful laser-assisted in situ keratomileusis (LASIK). Methods: Eighteen postmortem corneas from 10 patients with postoperative intervals of 2 to 8 years after LASIK surgery and 4 normal control corneas from 2 patients were collected from US eye banks and processed for histologic analysis and immunolocalization with antibodies to MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, and MMP-14. Results: Matrix metalloproteinase 7 was present in the epithelium of all corneas. Other MMPs were localized to the wound margin in some post-LASIK corneas. Matrix metalloproteinase 9 was detected around epithelial cells trapped in the lamellar scar in 5 of 6 corneas with epithelial ingrowth. Various MMPs were detected in fibrotic tissue at the wound margin in 2 of 2 corneas with flap retraction. Conclusions: The presence of MMPs in post-LASIK corneas correlates with an ongoing wound healing process associated with minor post-LASIK complications. Matrix metalloproteinases might contribute to instances of ongoing flap instability, and if so, judicious use of MMP inhibitors could provide benefit. |
| معلومات مُعتمدة: | P30-EY014801 United States EY NEI NIH HHS; R01-EY00933 United States EY NEI NIH HHS; R01-EY012651 United States EY NEI NIH HHS |
| المشرفين على المادة: | EC 3.4.24.- (Matrix Metalloproteinases) |
| تواريخ الأحداث: | Date Created: 20080213 Date Completed: 20080307 Latest Revision: 20150417 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1001/archophthalmol.2007.64 |
| PMID: | 18268205 |
| قاعدة البيانات: | MEDLINE |
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