دورية أكاديمية
[Effect of medicinal preparations on the complement: inhibition of subcomponent C1q binding to a target].
| العنوان: | [Effect of medicinal preparations on the complement: inhibition of subcomponent C1q binding to a target]. |
|---|---|
| المؤلفون: | Bichucher AM, Kozlov LV |
| المصدر: | Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2007 Nov-Dec; Vol. 70 (6), pp. 25-8. |
| نوع المنشور: | Evaluation Study; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Izd-vo Meditsina Country of Publication: Russia (Federation) NLM ID: 9215981 Publication Model: Print Cited Medium: Print ISSN: 0869-2092 (Print) Linking ISSN: 08692092 NLM ISO Abbreviation: Eksp Klin Farmakol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : Izd-vo Meditsina |
| مواضيع طبية MeSH: | Complement C1q/*antagonists & inhibitors , Complement Inactivating Agents/*isolation & purification , Complement Pathway, Classical/*drug effects , Drug Evaluation, Preclinical/*methods, Complement Inactivating Agents/pharmacology ; Humans ; Immunoenzyme Techniques |
| مستخلص: | A method is developed for determining the inhibition constants of substances capable of acting on the complement system at the stage of target recognition (immune complexes) by the first component of the complement (and, hence, blocking activation of the classical pathway of the complement). The ability of some drugs to inhibit the binding of subcomponent C1q to a target has been studied. It is shown that some drugs possess a pronounced ability to block the complement activation. The inhibition constants are compared to the therapeutic dozes of drugs. Some of the investigated preparations (suramin, sodium deoxiribonucleate, curcumin, heparin, sulfetron, guttalax, lysozyme) upon administration can present in the blood flow in concentrations capable of blocking the complement. The method is useful in the search for preparations capable of inhibiting the complement and in the study of side effects of medicinal preparations. |
| المشرفين على المادة: | 0 (Complement Inactivating Agents) 80295-33-6 (Complement C1q) |
| تواريخ الأحداث: | Date Created: 20080306 Date Completed: 20080421 Latest Revision: 20191210 |
| رمز التحديث: | 20221213 |
| PMID: | 18318191 |
| قاعدة البيانات: | MEDLINE |
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