دورية أكاديمية
Lead-associated endocarditis: the important role of methicillin-resistant Staphylococcus aureus.
| العنوان: | Lead-associated endocarditis: the important role of methicillin-resistant Staphylococcus aureus. |
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| المؤلفون: | Greenspon AJ; Division of Cardiology, Department of Medicine, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107, USA. arnold.greenspon@jefferson.edu, Rhim ES, Mark G, Desimone J, Ho RT |
| المصدر: | Pacing and clinical electrophysiology : PACE [Pacing Clin Electrophysiol] 2008 May; Vol. 31 (5), pp. 548-53. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Futura Pub. Co. Country of Publication: United States NLM ID: 7803944 Publication Model: Print Cited Medium: Internet ISSN: 1540-8159 (Electronic) Linking ISSN: 01478389 NLM ISO Abbreviation: Pacing Clin Electrophysiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Mount Kisco, N. Y. : Futura Pub. Co., c1978- |
| مواضيع طبية MeSH: | Methicillin Resistance*, Defibrillators, Implantable/*statistics & numerical data , Electrodes, Implanted/*statistics & numerical data , Endocarditis/*epidemiology , Pacemaker, Artificial/*statistics & numerical data , Prosthesis-Related Infections/*epidemiology , Staphylococcal Infections/*epidemiology, Adult ; Aged ; Aged, 80 and over ; Endocarditis/prevention & control ; Female ; Humans ; Male ; Middle Aged ; Outcome Assessment, Health Care ; Pennsylvania/epidemiology ; Prevalence ; Retrospective Studies ; Risk Assessment/methods ; Risk Factors ; Staphylococcal Infections/drug therapy ; Treatment Outcome |
| مستخلص: | Background: Infection is a potentially life-threatening complication of cardiac device implantation. Lead-associated endocarditis (LAE) may be the most serious complication since it is associated with a high mortality. Methods: The medical records of patients referred to our institution for the treatment of LAE between 1999 and 2007 were reviewed. Results: A total of 51 of 107 patients referred for device-related infections met the criteria for LAE. Of these, 19 occurred within 6 months of their most recent procedure (early), while the remaining 32 occurred more than 6 months later (mean = 31.9 months post procedure). Devices included pacemakers in 33 patients and ICDs in 18 patients. The most common organism responsible for infection was Staphylococcus aureus (S. aureus) followed by coagulase-negative staphylocci (22%) and streptococci (12%). Methicillin-resistant S. aureus (MRSA) accounted for 67% of the S. aureus infections. Coagulase-negative staphylococci were responsible for only 26% of early and 19% of late cases. A distant site of infection was common (26/51 = 51%), particularly in patients with MRSA LAE. The device and leads were removed percutaneously in all patients. Only one patient failed to respond to intravenous antibiotics. Conclusions: Our data suggest that methicillin-resistant S. aureus is an important pathogen in LAE. Since many infections occur months after the last device procedure, hematogenous spread of organisms from a distant site may be an important contributing factor. These data suggest that strategies to prevent hematogenous infection, particularly with S. aureus, are critical in patients with implantable cardiac devices. |
| تواريخ الأحداث: | Date Created: 20080429 Date Completed: 20080528 Latest Revision: 20191210 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/j.1540-8159.2008.01039.x |
| PMID: | 18439167 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1540-8159 |
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| DOI: | 10.1111/j.1540-8159.2008.01039.x |