دورية أكاديمية
Structural genomics of pathogenic protozoa: an overview.
| العنوان: | Structural genomics of pathogenic protozoa: an overview. |
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| المؤلفون: | Fan E; Department of Biochemistry, University of Washington, Seattle, WA, USA., Baker D, Fields S, Gelb MH, Buckner FS, Van Voorhis WC, Phizicky E, Dumont M, Mehlin C, Grayhack E, Sullivan M, Verlinde C, Detitta G, Meldrum DR, Merritt EA, Earnest T, Soltis M, Zucker F, Myler PJ, Schoenfeld L, Kim D, Worthey L, Lacount D, Vignali M, Li J, Mondal S, Massey A, Carroll B, Gulde S, Luft J, Desoto L, Holl M, Caruthers J, Bosch J, Robien M, Arakaki T, Holmes M, Le Trong I, Hol WG |
| المصدر: | Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2008; Vol. 426, pp. 497-513. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Print ISSN: 1064-3745 (Print) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Totowa, NJ : Humana Press Original Publication: Clifton, N.J. : Humana Press, |
| مواضيع طبية MeSH: | Genomics/*methods , Plasmodium/*genetics , Protozoan Proteins/*chemistry , Trypanosomatina/*genetics, Animals ; Crystallization ; Crystallography, X-Ray/methods |
| مستخلص: | The Structural Genomics of Pathogenic Protozoa (SGPP) Consortium aimed to determine crystal structures of proteins from trypanosomatid and malaria parasites in a high throughput manner. The pipeline of target selection, protein production, crystallization, and structure determination, is sketched. Special emphasis is given to a number of technology developments including domain prediction, the use of "co-crystallants," and capillary crystallization. "Fragment cocktail crystallography" for medical structural genomics is also described. |
| Number of References: | 33 |
| معلومات مُعتمدة: | GM 064655 United States GM NIGMS NIH HHS |
| المشرفين على المادة: | 0 (Protozoan Proteins) |
| تواريخ الأحداث: | Date Created: 20080611 Date Completed: 20080818 Latest Revision: 20220112 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/978-1-60327-058-8_33 |
| PMID: | 18542886 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1064-3745 |
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| DOI: | 10.1007/978-1-60327-058-8_33 |