دورية أكاديمية
أعرض في EDS

TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer.

التفاصيل البيبلوغرافية
العنوان: TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer.
المؤلفون: Linger RM; Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, Aurora, CO, USA., Keating AK, Earp HS, Graham DK
المصدر: Advances in cancer research [Adv Cancer Res] 2008; Vol. 100, pp. 35-83.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0370416 Publication Model: Print Cited Medium: Print ISSN: 0065-230X (Print) Linking ISSN: 0065230X NLM ISO Abbreviation: Adv Cancer Res Subsets: MEDLINE
أسماء مطبوعة: Publication: <2008>- : Amsterdam : Elsevier
Original Publication: New York : Academic Press
مواضيع طبية MeSH: Neoplasms/*etiology , Neoplasms/*therapy , Oncogene Proteins/*physiology , Proto-Oncogene Proteins/*physiology , Receptor Protein-Tyrosine Kinases/*physiology, Animals ; Cell Survival ; Drug Delivery Systems ; Humans ; Models, Biological ; Neoplasm Invasiveness/genetics ; Neoplasms/genetics ; Neoplasms/pathology ; Neovascularization, Pathologic/genetics ; Oncogene Proteins/antagonists & inhibitors ; Oncogene Proteins/genetics ; Oncogene Proteins/metabolism ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins/antagonists & inhibitors ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Receptor Protein-Tyrosine Kinases/genetics ; Receptor Protein-Tyrosine Kinases/metabolism ; Signal Transduction/physiology ; Tumor Burden/genetics ; c-Mer Tyrosine Kinase ; Axl Receptor Tyrosine Kinase
مستخلص: Tyro-3, Axl, and Mer constitute the TAM family of receptor tyrosine kinases (RTKs) characterized by a conserved sequence within the kinase domain and adhesion molecule-like extracellular domains. This small family of RTKs regulates an intriguing mix of processes, including cell proliferation/survival, cell adhesion and migration, blood clot stabilization, and regulation of inflammatory cytokine release. Genetic or experimental alteration of TAM receptor function can contribute to a number of disease states, including coagulopathy, autoimmune disease, retinitis pigmentosa, and cancer. In this chapter, we first provide a comprehensive review of the structure, regulation, biologic functions, and downstream signaling pathways of these receptors. In addition, we discuss recent evidence which suggests a role for TAM receptors in oncogenic mechanisms as family members are overexpressed in a spectrum of human cancers and have prognostic significance in some. Possible strategies for targeted inhibition of the TAM family in the treatment of human cancer are described. Further research will be necessary to evaluate the full clinical implications of TAM family expression and activation in cancer.
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معلومات مُعتمدة: T32 CA082086 United States CA NCI NIH HHS; T32 CA082086-10 United States CA NCI NIH HHS
المشرفين على المادة: 0 (Oncogene Proteins)
0 (Protein Kinase Inhibitors)
0 (Proto-Oncogene Proteins)
EC 2.7.10.1 (MERTK protein, human)
EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
EC 2.7.10.1 (TYRO3 protein, human)
EC 2.7.10.1 (c-Mer Tyrosine Kinase)
0 (Axl Receptor Tyrosine Kinase)
0 (AXL protein, human)
تواريخ الأحداث: Date Created: 20080716 Date Completed: 20080808 Latest Revision: 20221207
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC3133732
DOI: 10.1016/S0065-230X(08)00002-X
PMID: 18620092
قاعدة البيانات: MEDLINE
الوصف
تدمد:0065-230X
DOI:10.1016/S0065-230X(08)00002-X