دورية أكاديمية
Efficacy of the tubercidin antileishmania action associated with an inhibitor of the nucleoside transport.
| العنوان: | Efficacy of the tubercidin antileishmania action associated with an inhibitor of the nucleoside transport. |
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| المؤلفون: | Aoki JI; Dept. Moléstias Infecciosas e Parasitárias, Instituto de Medicina Tropical, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 4704 degrees andar, São Paulo, SP 05403-000, Brazil., Yamashiro-Kanashiro EH, Ramos DC, Cotrim PC |
| المصدر: | Parasitology research [Parasitol Res] 2009 Jan; Vol. 104 (2), pp. 223-8. Date of Electronic Publication: 2008 Sep 12. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 8703571 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0932-0113 (Print) Linking ISSN: 09320113 NLM ISO Abbreviation: Parasitol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : Springer International, c1987- |
| مواضيع طبية MeSH: | Antiparasitic Agents/*therapeutic use , Enzyme Inhibitors/*therapeutic use , Leishmania/*drug effects , Leishmaniasis/*drug therapy , Thioinosine/*analogs & derivatives , Thionucleotides/*therapeutic use , Tubercidin/*therapeutic use, Animals ; Antiparasitic Agents/pharmacology ; Antiparasitic Agents/toxicity ; Cells, Cultured ; Drug Therapy, Combination ; Enzyme Inhibitors/pharmacology ; Macrophages/drug effects ; Macrophages/parasitology ; Mice ; Mice, Inbred BALB C ; Schistosoma mansoni/drug effects ; Thioinosine/pharmacology ; Thioinosine/therapeutic use ; Thionucleotides/pharmacology ; Trypanosoma brucei gambiense/drug effects ; Tubercidin/pharmacology ; Tubercidin/toxicity |
| مستخلص: | Tubercidin (TUB) is an adenosine analog with potent antiparasite action, unfortunately associated with severe host toxicity. Prevention of TUB toxicity can be reached associating nitrobenzylthioinosine (NBMPR), an inhibitor of the purine nucleoside transport, specifically target to the mammal cells. It was demonstrated that this nucleoside transport inhibitor has no significant effect in the in vitro uptake of TUB by Schistosoma mansoni and Trypanosoma gambiense. Seeking to evaluate if the association of these compounds is also effective against leishmania, we analyzed the TUB-NBMPR combined treatment in in vitro cultures of promastigote forms of Leishmania (L.) amazonensis, Leishmania (L.) chagasi, Leishmania (L.) major, and Leishmania (V.) braziliensis as well as in cultures of amastigote forms of L. (L.) amazonensis, mice macrophages infected with L. (L.) amazonensis, and in vivo tests in BALB/c mice infected with L. (L.) amazonensis. We demonstrated that TUB-NBMPR combined treatment can be effective against leishmania cells protecting mammalian cells from TUB toxicity. |
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| المشرفين على المادة: | 0 (Antiparasitic Agents) 0 (Enzyme Inhibitors) 0 (Thionucleotides) 46S541971T (Thioinosine) 65199-10-2 (nitrobenzylthioinosine 5'-monophosphate) M351LCX45Y (Tubercidin) |
| تواريخ الأحداث: | Date Created: 20080913 Date Completed: 20090416 Latest Revision: 20211020 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s00436-008-1177-z |
| PMID: | 18787843 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 0932-0113 |
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| DOI: | 10.1007/s00436-008-1177-z |