دورية أكاديمية
[Subclinical acute rejections in protocol biopsies at 3 months after kidney transplantation].
| العنوان: | [Subclinical acute rejections in protocol biopsies at 3 months after kidney transplantation]. |
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| عنوان ترانسليتريتد: | Subklinické akutní rejekce v protokolárních biopsiích 3 mesíce po transplantaci ledviny. |
| المؤلفون: | Matl I; Klinika nefrologie IKEM, Praha. ivo.matl@ikem.cz, Honsová E, Lodererová A, Lánská V, Viklický O |
| المصدر: | Vnitrni lekarstvi [Vnitr Lek] 2008 Nov; Vol. 54 (11), pp. 1054-8. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Czech |
| بيانات الدورية: | Publisher: Ambit Media Country of Publication: Czech Republic NLM ID: 0413602 Publication Model: Print Cited Medium: Print ISSN: 0042-773X (Print) Linking ISSN: 0042773X NLM ISO Abbreviation: Vnitr Lek Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2010- : Brno : Ambit Media Original Publication: 1973-<1994> : Praha : Avicenum |
| مواضيع طبية MeSH: | Biopsy, Needle* , Kidney Transplantation*, Graft Rejection/*diagnosis , Kidney/*pathology, Acute Disease ; Female ; Graft Rejection/pathology ; Humans ; Male ; Middle Aged |
| مستخلص: | Aim: The primary aim of the study was detection of subclinical acute rejection and borderline changes in protocol biopsies at 3 months after transplantation, and assessment of possible clinical and laboratory associations. Methods: Biopsy was carried out in 194 patients with stabilized graft function. Patients were treated with immunosuppressive regimen based on cyclosporine A (n = 34), tacrolimus (n = 152), or sirolimus/everolimus (n = 10). Samples were processed by standard paraffine technique, and stained according to laboratory protocol. All samples were tested by immunofluorescence or immunohistochemical procedures for C4d presence as a sign of humoral rejection. Results: Of 192 representative samples, subclinical acute rejection and borderline changes were found in 24 samples (12.5%). In patients with this finding, the mean serum creatinine was significantly higher (185.2 +/- 2.2 micromol/L), than in patients with normal finding (128.2 +/- 28.3 micromol/L) p < 0.001. Using the ROC curve analysis of serum creatinine, the cut-off point 170 micromol/L was found to discriminate normal findings from subclinical rejection and borderline changes. A significant correlation between acute rejections before protocol biopsy and subclinical acute rejections together with borderline changes in protocol biopsy was found. C4d positivity was found in 6 samples. Immunosuppressive therapy (cyclosporine versus tacrolimus) did not have any impact on subclinical acute rejections and borderline changes prevalence. Conclusions: The main conclusion of this study is a finding, that acute rejection early after renal transplantation and serum creatinine > or = 170 micromol/l at three months after transplantation are risks for development of subclinical acute rejection, even of humoral type, or borderline changes. |
| تواريخ الأحداث: | Date Created: 20081217 Date Completed: 20090122 Latest Revision: 20081216 |
| رمز التحديث: | 20221213 |
| PMID: | 19069678 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0042-773X |
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