دورية أكاديمية
Stereospecific high-performance liquid chromatographic determination of tocainide.
| العنوان: | Stereospecific high-performance liquid chromatographic determination of tocainide. |
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| المؤلفون: | Carr RA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada., Foster RT, Freitag D, Pasutto FM |
| المصدر: | Journal of chromatography [J Chromatogr] 1991 May 03; Vol. 566 (1), pp. 155-62. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0427043 Publication Model: Print Cited Medium: Print NLM ISO Abbreviation: J Chromatogr Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier. |
| مواضيع طبية MeSH: | Isocyanates*, Anti-Arrhythmia Agents/*blood , Chromatography, High Pressure Liquid/*methods , Lidocaine/*analogs & derivatives, Adult ; Anti-Arrhythmia Agents/pharmacokinetics ; Cyanates ; Humans ; Lidocaine/blood ; Lidocaine/pharmacokinetics ; Male ; Naphthalenes ; Stereoisomerism ; Tocainide |
| مستخلص: | A sensitive high-performance liquid chromatographic assay was developed for the determination of tocainide enantiomers in plasma. Following extraction of tocainide from plasma, the enantiomers were derivatized with S-(+)-1-(1-naphthyl)ethylisocyanate. The resulting diastereomers were separated and quantified using normal-phase chromatography with fluorescence detection set at 220/345 nm (excitation/emission). The peaks, resolved with a resolution factor greater than 1.5, were free from interference. Linearity was established over the concentration range 0.25-10.0 mg/l for each enantiomer in plasma (r2 greater than 0.998). The inter-assay variability was less than 10% at all concentrations examined. The method can be used to determine the pharmacokinetics of tocainide enantiomers in man. |
| المشرفين على المادة: | 0 (Anti-Arrhythmia Agents) 0 (Cyanates) 0 (Isocyanates) 0 (Naphthalenes) 27DXO59SAN (Tocainide) 42340-98-7 (1-(1-naphthyl)ethyl isocyanate) 98PI200987 (Lidocaine) |
| تواريخ الأحداث: | Date Created: 19910503 Date Completed: 19911004 Latest Revision: 20190629 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/0378-4347(91)80120-2 |
| PMID: | 1909341 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.1016/0378-4347(91)80120-2 |
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