دورية أكاديمية
Serial chimerism analyses indicate that mixed haemopoietic chimerism influences the probability of graft rejection and disease recurrence following allogeneic stem cell transplantation (SCT) for severe aplastic anaemia (SAA): indication for routine assessment of chimerism post SCT for SAA.
| العنوان: | Serial chimerism analyses indicate that mixed haemopoietic chimerism influences the probability of graft rejection and disease recurrence following allogeneic stem cell transplantation (SCT) for severe aplastic anaemia (SAA): indication for routine assessment of chimerism post SCT for SAA. |
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| المؤلفون: | Lawler M; Durkan Research Laboratories, Department of Haematology, Institute of Molecular Medicine, St James's Hospital and Trinity College, Dublin, Ireland. mplawler@tcd.ie, McCann SR, Marsh JC, Ljungman P, Hows J, Vandenberghe E, O'Riordan J, Locasciulli A, Socié G, Kelly A, Schrezenmeier H, Marin P, Tichelli A, Passweg JR, Dickenson A, Ryan J, Bacigalupo A |
| مؤلفون مشاركون: | Severe Aplastic Anaemia Working Party of the European Blood and Marrow Transplant Group |
| المصدر: | British journal of haematology [Br J Haematol] 2009 Mar; Vol. 144 (6), pp. 933-45. Date of Electronic Publication: 2009 Jan 09. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Wiley-Blackwell Original Publication: Oxford : Blackwell Scientific Publications |
| مواضيع طبية MeSH: | Graft Rejection*, Anemia, Aplastic/*therapy , Stem Cell Transplantation/*adverse effects, Adolescent ; Adult ; Anemia, Aplastic/genetics ; Anemia, Aplastic/mortality ; Child ; Child, Preschool ; Chimerism ; Cyclosporine/therapeutic use ; Fanconi Anemia/genetics ; Fanconi Anemia/mortality ; Fanconi Anemia/therapy ; Female ; Follow-Up Studies ; Humans ; Immunosuppressive Agents/therapeutic use ; Male ; Middle Aged ; Polymerase Chain Reaction/methods ; Prognosis ; Proportional Hazards Models ; Recurrence ; Survival Rate ; Tandem Repeat Sequences ; Time Factors ; Transplantation Conditioning ; Transplantation, Homologous ; Young Adult |
| مستخلص: | Ninety-one patients were studied serially for chimeric status following allogeneic stem cell transplantation (SCT) for severe aplastic anaemia (SAA) or Fanconi Anaemia (FA). Short tandem repeat polymerase chain reaction (STR-PCR) was used to stratify patients into five groups: (A) complete donor chimeras (n = 39), (B) transient mixed chimeras (n = 15) (C) stable mixed chimeras (n = 18), (D) progressive mixed chimeras (n = 14) (E) recipient chimeras with early graft rejection (n = 5). As serial sampling was not possible in Group E, serial chimerism results for 86 patients were available for analysis. The following factors were analysed for association with chimeric status: age, sex match, donor type, aetiology of aplasia, source of stem cells, number of cells engrafted, conditioning regimen, graft-versus-host disease (GvHD) prophylaxis, occurrence of acute and chronic GvHD and survival. Progressive mixed chimeras (PMCs) were at high risk of late graft rejection (n = 10, P < 0.0001). Seven of these patients lost their graft during withdrawal of immunosuppressive therapy. STR-PCR indicated an inverse correlation between detection of recipient cells post-SCT and occurrence of acute GvHD (P = 0.008). PMC was a bad prognostic indicator of survival (P = 0.003). Monitoring of chimeric status during cyclosporin withdrawal may facilitate therapeutic intervention to prevent late graft rejection in patients transplanted for SAA. |
| المشرفين على المادة: | 0 (Immunosuppressive Agents) 83HN0GTJ6D (Cyclosporine) |
| تواريخ الأحداث: | Date Created: 20090203 Date Completed: 20090526 Latest Revision: 20220331 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/j.1365-2141.2008.07533.x |
| PMID: | 19183198 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1365-2141 |
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| DOI: | 10.1111/j.1365-2141.2008.07533.x |