دورية أكاديمية
Marine toxins potently affecting neurotransmitter release.
| العنوان: | Marine toxins potently affecting neurotransmitter release. |
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| المؤلفون: | Meunier FA; Queensland Brain Institute and School of Biomedical Sciences, The University of Queensland, St. Lucia, Queensland 4061, Australia., Mattei C, Molgó J |
| المصدر: | Progress in molecular and subcellular biology [Prog Mol Subcell Biol] 2009; Vol. 46, pp. 159-86. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: United States NLM ID: 0233223 Publication Model: Print Cited Medium: Print ISSN: 0079-6484 (Print) Linking ISSN: 00796484 NLM ISO Abbreviation: Prog Mol Subcell Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, Springer-Verlag. |
| مواضيع طبية MeSH: | Calcium Channel Blockers/*toxicity , Calcium Channels/*physiology , Marine Toxins/*pharmacology , Neurotransmitter Agents/*antagonists & inhibitors , Neurotransmitter Agents/*physiology , Synaptic Transmission/*drug effects, Acrylamides/toxicity ; Amino Acid Sequence ; Animals ; Ciguatoxins/chemistry ; Ciguatoxins/toxicity ; Cnidarian Venoms ; Ion Channels/antagonists & inhibitors ; Ion Channels/physiology ; Marine Toxins/chemistry ; Marine Toxins/toxicity ; Models, Molecular ; Molecular Sequence Data ; Neurotoxins/toxicity ; Oxocins/toxicity ; Potassium Channels/drug effects ; Potassium Channels/physiology ; Saxitoxin/toxicity ; Sea Anemones ; Tetrodotoxin/toxicity |
| مستخلص: | Synapses are specialised structures where interneuronal communication takes place. Not only brain function is absolutely dependent on synaptic activity, but also most of our organs are intimately controlled by synaptic activity. Synapses re therefore an ideal target to act upon and poisonous species have evolved fascinating neurotoxins capable of shutting down neuronal communication by blocking or activating essential components of the synapse. By hijacking key proteins of the communication machinery, neurotoxins are therefore extremely valuable tools that have, in turn, greatly helped our understanding of synaptic biology. Moreover, analysis and understanding of the molecular strategy used by certain neurotoxins has allowed the design of entirely new classes of drugs acting on specific targets with high selectivity and efficacy. This chapter will discuss the different classes of marine neurotoxins, their effects on neurotransmitter release and how they act to incapacitate key steps in the process leading to synaptic vesicle fusion. |
| Number of References: | 165 |
| المشرفين على المادة: | 0 (Acrylamides) 0 (Calcium Channel Blockers) 0 (Calcium Channels) 0 (Cnidarian Venoms) 0 (Ion Channels) 0 (Marine Toxins) 0 (Neurotoxins) 0 (Neurotransmitter Agents) 0 (Oxocins) 0 (Potassium Channels) 11050-21-8 (Ciguatoxins) 35523-89-8 (Saxitoxin) 4368-28-9 (Tetrodotoxin) 98225-48-0 (brevetoxin) 9P59GES78D (maitotoxin) OQ17NC0MOV (palytoxin) |
| تواريخ الأحداث: | Date Created: 20090203 Date Completed: 20090427 Latest Revision: 20181201 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1007/978-3-540-87895-7_6 |
| PMID: | 19184588 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0079-6484 |
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| DOI: | 10.1007/978-3-540-87895-7_6 |