دورية أكاديمية
Hemocompatibility evaluation with experimental and computational fluid dynamic analyses for a monopivot circulatory assist pump.
| العنوان: | Hemocompatibility evaluation with experimental and computational fluid dynamic analyses for a monopivot circulatory assist pump. |
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| المؤلفون: | Nishida M; Institute for Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology Tsukuba, Ibaraki, Japan. masahiro.nishida@aist.go.jp, Maruyama O, Kosaka R, Yamane T, Kogure H, Kawamura H, Yamamoto Y, Kuwana K, Sankai Y, Tsutsui T |
| المصدر: | Artificial organs [Artif Organs] 2009 Apr; Vol. 33 (4), pp. 378-86. |
| نوع المنشور: | Comparative Study; Evaluation Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 7802778 Publication Model: Print Cited Medium: Internet ISSN: 1525-1594 (Electronic) Linking ISSN: 0160564X NLM ISO Abbreviation: Artif Organs Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge, MA : Wiley-Blackwell Original Publication: Cleveland, International Society for Artificial Organs. |
| مواضيع طبية MeSH: | Biocompatible Materials* , Computer Simulation* , Heart-Assist Devices*/adverse effects , Hemolysis* , Hemorheology* , Models, Cardiovascular* , Numerical Analysis, Computer-Assisted*, Thrombosis/*prevention & control, Animals ; Cattle ; Equipment Design ; Materials Testing ; Reproducibility of Results ; Stress, Mechanical ; Thrombosis/etiology |
| مستخلص: | The hemocompatibility of a newly developed monopivot circulatory assist pump was evaluated by the computational fluid dynamic (CFD) analyses with the particle tracking velocimetry measurement. Results were compared with those of the hemolysis test and in vitro antithrombogenic test to prevent hemolysis and thrombus formation inside the pump. The results of the CFD analysis and the particle tracking velocimetry had a good agreement with each other. The flow distributions by the CFD analysis indicated that the radial jet out of the impeller was adequately weak so that the wall shear stress was lower than 300 Pa on the volute casing wall. It corresponded with the hemolysis tests results, indicating that the hemolysis level was lower than that of the commercially available pump. However, the flow distributions also indicated that the pivot that was easy to stagnate was washed out, not only by the secondary flow through the back gap of the impeller, but also by the vortices generated by the secondary vanes. It corresponded with the in vitro antithrombogenic test results, indicating that thrombus formation could be removed only by redesigning the geometry of the secondary vanes. |
| المشرفين على المادة: | 0 (Biocompatible Materials) |
| تواريخ الأحداث: | Date Created: 20090402 Date Completed: 20090611 Latest Revision: 20191210 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1111/j.1525-1594.2009.00730.x |
| PMID: | 19335415 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1525-1594 |
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| DOI: | 10.1111/j.1525-1594.2009.00730.x |