التفاصيل البيبلوغرافية
| العنوان: |
Frequency of CYP1A2 polymorphism in beagle dogs. |
| المؤلفون: |
Whiterock VJ; Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Company, Wallingford, CT 06492, USA. valerie.whiterock@bms.com, Delmonte TA, Hui LE, Orcutt TL, Sinz MW |
| المصدر: |
Drug metabolism letters [Drug Metab Lett] 2007 Apr; Vol. 1 (2), pp. 163-5. |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101313587 Publication Model: Print Cited Medium: Internet ISSN: 1874-0758 (Electronic) Linking ISSN: 18723128 NLM ISO Abbreviation: Drug Metab Lett Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Saif Zone, Sharjah, U.A.E. : Bentham Science Publishers |
| مواضيع طبية MeSH: |
Gene Frequency* , Polymorphism, Single Nucleotide*, Cytochrome P-450 CYP1A2/*genetics, Animals ; Dogs ; Female ; Heterozygote ; Homozygote ; Male ; Mutation |
| مستخلص: |
A single nucleotide polymorphism in the dog CYP1A2 gene causes these animals to be CYP1A2 deficient (i.e., lack functional CYP1A2 enzyme activity). Genotyping a colony of 79 dogs revealed 77% wild-type, 19% heterozygous, and 4% homozygous mutant animals. These genetic frequencies are significantly different from those previously reported and illustrate that different sources and populations of dogs can have dramatically different frequencies of this polymorphism. |
| المشرفين على المادة: |
EC 1.14.14.1 (Cytochrome P-450 CYP1A2) |
| تواريخ الأحداث: |
Date Created: 20090410 Date Completed: 20090427 Latest Revision: 20191111 |
| رمز التحديث: |
20221213 |
| DOI: |
10.2174/187231207780363688 |
| PMID: |
19356037 |
| قاعدة البيانات: |
MEDLINE |
